Pimonidazole Chemical Properties

Melting point:

110-113°C

Boiling point:

490.5±55.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: >20mg/mL

pka

14.06±0.20(Predicted)

form 

powder

color 

yellow

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Pimonidazole Usage And Synthesis

Description

Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck. This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.

Uses

Pimonidazole is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It labels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.

Biochem/physiol Actions

Pimonidazole is an effective and nontoxic exogenous 2-nitroimidazole hypoxia marker. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids.

storage

Store at -20°C

References

[1] JOHANNES H A M KAANDERS. Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.[J]. Cancer research, 2002, 62 23: 7066-7074.

Pimonidazole(70132-50-2)Related Product Information

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