Basic information Safety Supplier Related

Pimonidazole

Basic information Safety Supplier Related

Pimonidazole Basic information

Product Name:
Pimonidazole
Synonyms:
  • Pimonidazole
  • 1-(2-Nitro-1H-imidazol-1-yl)-3-(piperidin-1-yl)-2-propanol
  • α-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol
  • alpha-((2-Nitroimidazol-1-yl)methyl)-1-piperidineethanol
  • alpha-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol
  • NSC 380540
  • 1-(2-nitroimidazol-1-yl)-3-piperidin-1-ylpropan-2-ol
  • 1-Piperidineethanol, α-[(2-nitro-1H-imidazol-1-yl)methyl]-
CAS:
70132-50-2
MF:
C11H18N4O3
MW:
254.29
Mol File:
70132-50-2.mol
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Pimonidazole Chemical Properties

Melting point:
110-113°C
Boiling point:
490.5±55.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
pka
14.06±0.20(Predicted)
form 
powder
color 
yellow
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
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Pimonidazole Usage And Synthesis

Description

Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck. This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.

Uses

Pimonidazole is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It labels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.

Biochem/physiol Actions

Pimonidazole is an effective and nontoxic exogenous 2-nitroimidazole hypoxia marker. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids.

storage

Store at -20°C

PimonidazoleSupplier

ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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sales-cpd@caerulumpharma.com
Sigma-Aldrich
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021-61415566 800-8193336
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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sales@glpbio.cn
TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com