4-Amino-4H-1,2,4-triazole Chemical Properties

Melting point:

84-86 °C(lit.)

Boiling point:

255 °C(lit.)

Density 

1.59±0.1 g/cm3(Predicted)

refractive index 

1.7390 (estimate)

Flash point:

>230 °F

storage temp. 

Store below +30°C.

solubility 

methanol: 0.1 g/mL, clear

form 

Crystalline Powder

pka

3.20±0.10(Predicted)

color 

White to off-white or beige

PH

<7 (H2O, 20℃)

Water Solubility 

810 g/L (20 ºC)

BRN 

107563

InChIKey

FMCUPJKTGNBGEC-UHFFFAOYSA-N

CAS DataBase Reference

584-13-4(CAS DataBase Reference)

EPA Substance Registry System

4-Amino-1,2,4-triazole (584-13-4)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-42/43

Safety Statements 

26-36

WGK Germany 

3

RTECS 

XZ3850200

F 

8

Hazard Note 

Irritant

HS Code 

2933 99 80

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Amino-4H-1,2,4-triazole Usage And Synthesis

Chemical Properties

white to off-white or beige crystalline powder

Uses

1,2,4-Triazol-4-amine is an intermediate used to prepare potent, selective, and orally active cyclooxygenase-?2 inhibitors. It is also used to synthesize hydroxyphenacyl azoles and related azolium derivatives as antifungal agents.

Purification Methods

It crystallises from EtOH/ Et2O or H2O. The hydrochloride has m 151-152o (from EtOH, 1g/10mL). [Allen & Bell Org Synth Coll Vol III 96 1955, Barszez et al. J Chem Soc, Dalton Trans 2025 1986, Beilstein 26 H 16, 26 II 7, 26 III/IV 40, Temple & Montgomery 1,2,4-Triazoles —The Chemistry of Heterocyclic Compounds Vol 37 (Weissberger & Taylor eds.). Wiley & Sons NY 1981, ISBN 0-471-0656-6.]

4-Amino-4H-1,2,4-triazole(584-13-4)Related Product Information

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