ChemicalBook > Product Catalog > API > Antineoplastic agents > Other antineoplastic Drugs > Catharanthine
Catharanthine
Catharanthine Basic information
- Product Name:
- Catharanthine
- Synonyms:
-
- (+)-3,4-didehydrocoronaridine
- 18-beta)-lph
- catharanthin
- ibogamine-18-carboxylicacid,3,4-didehydro-,methylester,(2-alpha,5-beta,6-a
- 7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1′,2′:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester
- Catharanthine, 98%, from Catharanthus roseus (L.) G. Don
- 4-Didehydrocoronaridine
- methyl(2-alpha,5-beta,6-alpha,18-beta)-3,4-didehydroibogamine-18-carboxylate
- CAS:
- 2468-21-5
- MF:
- C21H24N2O2
- MW:
- 336.43
- EINECS:
- 219-586-6
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Inhibitors
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Heterocycles
- Mol File:
- 2468-21-5.mol
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Catharanthine Chemical Properties
- Melting point:
- 138-1400C
- alpha
- D27 +29.8° (CHCl3)
- Boiling point:
- 472.9°C (rough estimate)
- Density
- 1.1367 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: soluble5mg/mL (clear solution; warmed)
- form
- powder
- pka
- 6.8(at 25℃)
- color
- white to beige
- optical activity
- [α]/D +30 to +38° (c=0.5, CDCl3)
- InChI
- InChI=1/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/s3
- InChIKey
- CMKFQVZJOWHHDV-XWQFPIRHNA-N
- SMILES
- [C@]12(C(=O)OC)C[C@]3([H])C=C(CC)[C@@]1([H])[N@](CCC1C4=C(C=CC=C4)NC2=1)C3 |&1:0,6,12,14,r|
MSDS
- Language:English Provider:Catharanthine
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Catharanthine Usage And Synthesis
Chemical Properties
Off-White to Pale Beige Solid
Uses
Precursor of Vinblastine-type alkaloids
Uses
Anticancer
Uses
Catharanthine is an indole alkaloid analog and an inhibitor of TRPM8.
Definition
ChEBI: Catharanthine is an organic heteropentacyclic compound and monoterpenoid indole alkaloid produced by the medicinal plant Catharanthus roseus via strictosidine. It is a bridged compound, an organic heteropentacyclic compound, a methyl ester, a monoterpenoid indole alkaloid, a tertiary amino compound and an alkaloid ester. It is a conjugate base of a catharanthine(1+).
target
NO | Calcium Channel | Nicotinic receptor
CatharanthineSupplier
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