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Trepibutone

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Trepibutone Basic information

Product Name:
Trepibutone
Synonyms:
  • 2,4,5-triethoxy-gamma-oxobenzenebutanoicacid
  • 3-(2,4,5-triethoxybenzoyl)-propionicaci
  • 3-(2,4,5-triethoxybenzoyl)propionicacid
  • aa149
  • colibil
  • supacal
  • TREPIBUTONE
  • 4-Oxo-4-(2,4,5-triethoxyphenyl)butanoic acid
CAS:
41826-92-0
MF:
C16H22O6
MW:
310.34
Mol File:
41826-92-0.mol
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Trepibutone Chemical Properties

Melting point:
150-151°
Boiling point:
370.51°C (rough estimate)
Density 
1.1625 (rough estimate)
refractive index 
1.4600 (estimate)
pka
4.40±0.17(Predicted)
form 
Solid
color 
White to off-white
CAS DataBase Reference
41826-92-0(CAS DataBase Reference)
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Trepibutone Usage And Synthesis

Originator

Supacal,Takeda,Japan,1981

Definition

ChEBI: Trepibutone is an organic molecular entity.

Manufacturing Process

To a mixture of 7.5 parts by weight of 1,2,4-triethoxybenzene, 40 parts by volume of tetrachloroethane and 7.5 parts by weight of succinic anhydride are added 23 parts by weight of anhydrous aluminum chloride. The mixture is stirred for 1 hour at 25°C and for another 2 hours at 60°C. After addition of 50 parts by weight of ice and 50 parts by volume of concentrated hydrochloric acid, the reaction mixture is subjected to steam distillation.
After cooling crystals separated from the remaining liquid are collected by filtration and recrystallized from aqueous ethanol, whereby 2.5 parts by weight of 3-(2',4',5'-triethoxybenzoyl)-propionic acid are obtained as colorless needles, melting point 150°C to 151°C.

Therapeutic Function

Choleretic

Trepibutone Preparation Products And Raw materials

Raw materials

TrepibutoneSupplier

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