Desoxypodophyllotoxin
Desoxypodophyllotoxin Basic information
- Product Name:
- Desoxypodophyllotoxin
- Synonyms:
-
- Desoxypodophyllotoxin
- anthric
- Anthricin/Deoxypodophyllotoxin
- 4-Deoxypodophyllotoxin
- Furo[3',4':6,7]naphtho[2,3-D]-1,3-dioxol-6(5ah)-one, 5,8,8A,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-,(5R,5ar,8ar)-
- Nsc403148
- Deoxypodophyllotoxin, deoxypodophyllotoxin
- Podophyllotoxin 9-Desoxy Impurity
- CAS:
- 19186-35-7
- MF:
- C22H22O7
- MW:
- 398.41
- Mol File:
- 19186-35-7.mol
Desoxypodophyllotoxin Chemical Properties
- storage temp.
- Store at 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- Boiling point:
- 564.5±50.0 °C(Predicted)
- Density
- 1.304±0.06 g/cm3(Predicted)
- Melting point:
- 168 °C
- color
- White to off-white
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1
- InChIKey
- ZGLXUQQMLLIKAN-SVIJTADQSA-N
- SMILES
- O1C2=CC3=C(C=C2OC1)[C@@H](C1=CC(OC)=C(OC)C(OC)=C1)[C@@]1([H])C(=O)OC[C@]1([H])C3
Desoxypodophyllotoxin Usage And Synthesis
Chemical Properties
Colorless prismatic crystals (anhydrous ethanol), soluble in methanol, ethanol, DMSO and other organic solvents, from the rhizomes of Sinopodophyllum hexandrum (Royle) Ying; Dysosma versipellis (Hance) M. Cheng ex Ying.
Uses
4-Deoxypodophyllotoxin is a medicinal herb product isolated from Anthriscus sylvestris Hoffm. It is well known for its antitumor, antiviral, and anti-inflammatory activities. 4-Deoxypodophyllotoxin wa s also shown to inhibit the passive cutaneous anaphylaxis reaction.
Definition
ChEBI: A member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted a position 5 by a 3,4,5-trimethoxyphenyl group.
in vivo
Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively[1].
| Animal Model: | Xenograft model of gastric cancer in nude mice with SGC-7901 cells[1] |
| Dosage: | 5, 10, and 20 mg/kg |
| Administration: | Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days |
| Result: | Inhibited the growth of gastric cancer tumors. |
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