l-Pimobendan
l-Pimobendan Basic information
- Product Name:
- l-Pimobendan
- Synonyms:
-
- l-Pimobendan
- i-Pimobendan
- CAS:
- 118428-37-8
- MF:
- C19H18N4O2
- MW:
- 334.37
- Mol File:
- 118428-37-8.mol
l-Pimobendan Chemical Properties
- Boiling point:
- 471.18°C (rough estimate)
- Density
- 1.2421 (rough estimate)
- refractive index
- 1.6620 (estimate)
- pka
- 10.21±0.10(Predicted)
l-Pimobendan Usage And Synthesis
Uses
(-)-Pimobedan is an isomer of pimobedan. It has the property of stereoselective partitioning or distribution into erythrocytes. The clearance of (-)-pimobedan from erythrocytes is significantly lower than that of (+)-pimobedan, which is entirely due to its stereoselective distribution into erythrocytes. This stereoselective property of (-)-pimobedan may explain the phenomenon previously reported that it produces a 1.5-fold greater contractile force than the (+)-isomer in detergent-treated myocardial specimens of guinea pigs and dogs. These properties suggest that (-)-pimobedan may have unique advantages in terms of in vivo distribution and pharmacological action, which may have important implications for its clinical use.
Definition
ChEBI: Pimobendan is a pyridazinone and a member of benzimidazoles. It has a role as a cardiotonic drug, a vasodilator agent and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.
References
[1] Plasma and red blood cell pharmacokinetics of pimobendan enantiomers in healthy Chinese