NADA
NADA Basic information
- Product Name:
- NADA
- Synonyms:
-
- ARACHIDONOYLDOPAMIDE
- ARACHIDONOYL DOPAMINE
- AA-DA
- NADA
- N-ARACHIDONOYL-3-HYDROXYTYRAMINE
- N-ARACHIDONOYLDOPAMINE
- N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
- N-(3,4-Dihydroxyphenethyl)acetamide
- CAS:
- 199875-69-9
- MF:
- C28H41NO3
- MW:
- 439.63
- Product Categories:
-
- Cannabinoid receptor
- Cannabinoid
- Mol File:
- 199875-69-9.mol
NADA Chemical Properties
- Boiling point:
- 640.0±55.0 °C(Predicted)
- Density
- 1.023±0.06 g/cm3(Predicted)
- Flash point:
- 14 °C
- storage temp.
- −20°C
- solubility
- Soluble in DMSO (up to 50 mg/ml).
- pka
- 9.79±0.10(Predicted)
- form
- ethanol solution
- color
- Pale yellow
- Sensitive
- Air Sensitive
- Stability:
- Stable for 2 years from date of purchase as supplied. Subject to air oxidation Solutions in DMSO may be stored at -80° under an inert atmosphere for up to 1 month.
Safety Information
- Hazard Codes
- F,Xi
- Risk Statements
- 11-36/37/38
- Safety Statements
- 16-26-36
- RIDADR
- UN 1170 3/PG 2
- WGK Germany
- 1
MSDS
- Language:English Provider:SigmaAldrich
NADA Usage And Synthesis
Description
N-Arachidonoyldopamine (199875-69-9) is an endogenous conjugate of arachidonic acid and dopamine.1?May be the “endogenous capsaicin like substance” in the CNS acting at TRPV1 channels, EC50~ 50 nM1. Also acts as a selective cannabinoid CB1 agonist (Ki=0.25 and 15 μM for CB1 and CB2 respectively)2?and results in a distinct signaling profile from any known cannabinoid3. Competitive inhibitor of FAAH and anandamide transport.4. Modulates acute systemic inflammation via non-hematopoietic TRPV1.5
Uses
NADA is a endogenous CB1 agonist, as well as a vanilloid agonist and inhibitor of FAAH and AMT.
Definition
ChEBI: Arachidonoyl dopamine is a fatty amide, a member of catechols, a secondary carboxamide and a N-(fatty acyl)-dopamine. It is functionally related to a dopamine and an arachidonic acid.
Biological Activity
Potent endogenous cannabinoid and vanilloid receptor agonist, with no action at dopamine receptors. Selective for CB 1 over CB 2 receptors (K i values are 0.25 and 12 μ M respectively), and potent agonist at TRPV1 (VR1) receptors (EC 50 ~ 50 nM). Metabolically stable and competitively inhibits FAAH and anandamide transport. Has cannabinoid and vanilloid actions in vivo . Also available as part of the Endocannabinoid Tocriset™ .
References
1) Huang?et al.?(2002),?An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors; Proc. Natl. Acad. Sci. USA,?99?8400 2) Bisogno?et al.?(2000),?N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo; Biochem. J.,?351 Pt 3?817 3) Redmund?et al.?(2016),?Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors; Br. J. Pharmacol.,?173?115 4) Petrocellis?et al.?(2000),?Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity; FEBS Lett.,?483?52 5) Lawton?et al.?(2017),?N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1; J. Immunol.,?199?1465
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