Basic information Safety Supplier Related

inogatran

Basic information Safety Supplier Related

inogatran Basic information

Product Name:
inogatran
Synonyms:
  • inogatran
  • H-314-27
  • Glycine, N-[(1R)-2-[(2S)-2-[[[3-[(aminoiminomethyl)amino]propyl]amino]carbonyl]-1-piperidinyl]-1-(cyclohexylmethyl)-2-oxoethyl]-
  • Inogatran (H-314-27)
CAS:
155415-08-0
MF:
C21H38N6O4
MW:
438.56
Mol File:
155415-08-0.mol
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inogatran Chemical Properties

Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
2.16±0.10(Predicted)
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inogatran Usage And Synthesis

Uses

Inogatran (H-314-27) is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of arterial and venous thrombotic diseases.

in vivo

Inogatran (H-314-27; 0.075, 0.25, 0.75 mg/kg, i.v.) results in dose-dependent increases in activated partial thromboplastin time (aPTT), thrombin time (TT), and prothrombin time (PT) in a canine electrolytic injury model of venous thrombosis[1].
Inogatran dose-dependently inhibits thrombus formation, which is measured as an increase in time to occlusion (TTO) and a decrease in thrombus weight. Inogatran also improves vena caval blood flow and reduces the overall incidence of thrombotic occlusion in a rat model[2].

References

[1] Ignasiak DP, et al. Effects of Intravenous Enoxaparin and Intravenous Inogatran in an Electrolytic Injury Model of Venous Thrombosis in the Dog. J Thromb Thrombolysis. 1998 Nov;6(3):199-206. DOI:10.1023/A:1008806312396
[2] Chi L, et al. Antithrombotic effect of LB-30057 (CI-1028), a new synthetic thrombin inhibitor, in a rabbit model of thrombosis: comparison with inogatran. J Thromb Thrombolysis. 2001 Feb;11(1):19-31. DOI:10.1023/a:1008900109285

inogatranSupplier

MedChemexpress LLC
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021-58955995
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sales@medchemexpress.cn
TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 15801484223;
Email
psaitong@jm-bio.com
TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
Suzhou Meishi Biotechnology Co., Ltd.
Tel
1173954148q
Email
meishipharma@126.com
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inogatran(155415-08-0)Related Product Information