methylnaltrexone
methylnaltrexone Basic information
- Product Name:
- methylnaltrexone
- Synonyms:
-
- methylnaltrexone
- 17-(Cyclopropylmethyl)-4,5α-epoxy-3-methoxy-14-hydroxymorphinan-6-one
- 3-Methoxy-14-hydroxy-17-(cyclopropylmethyl)-4,5α-epoxymorphinan-6-one
- 3-O-Methylnaltrexone
- 4,5α-Epoxy-3-methoxy-14β-hydroxy-17-(cyclopropylmethyl)morphinan-6-one
- Naltrexone methyl ether
- 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium
- 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinanium-6-one
- CAS:
- 83387-25-1
- MF:
- C21H26NO4+
- MW:
- 356.43544
- Mol File:
- 83387-25-1.mol
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methylnaltrexone Usage And Synthesis
Definition
ChEBI: Methylnaltrexone is a member of phenanthrenes.
General Description
Methylnaltrexone (Relistor) is the methylated, quaternaryform of naltrexone . The permanently chargednitrogen prevents the drug from crossing the blood-brainbarrier. Thus, it only acts as an antagonist at peripheralopioid receptors. Relistor was approved in April 2008 totreat opioid-induced constipation in patients receiving palliativecare. It is administered as a SC injection once everyother day.