Dextromethorphan hydrobromide monohydrate Chemical Properties

Melting point:

116-119°C

alpha 

[α]D25 +26～+30° (c=1.85, H2O)

Flash point:

11 °C

storage temp. 

Store at RT

solubility 

Sparingly soluble in water, freely soluble in ethanol (96 per cent).

form 

solid

color 

White to Off-White

PH

pH (10g/l, 25℃) : 5.2～6.5

BRN 

6453793

InChIKey

QYPSYPPSHXDFLV-UHFFFAOYSA-N

LogP

1.351 (est)

CAS DataBase Reference

6700-34-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

7-16-36/37-45

WGK Germany 

3

HS Code 

3822000002

Dextromethorphan hydrobromide monohydrate Usage And Synthesis

Description

Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant. However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC₅₀ = 0.55 μM) and nicotinic receptors (IC₅₀s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC₅₀ = 60 μM) and voltage-gated sodium channels (IC₅₀ = 78 μM). DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.

Chemical Properties

White Solid

Uses

Antitussive;Opioid ligand

Uses

An antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic). Racemethorphan and levomethorpham are controlled substances (opiates).

Definition

ChEBI: Dextromethorphan hydrobromide is the hydrobromide and monohydrate of the antitussive drug dextromethorphan. It is a hydrate and a hydrobromide. It contains a dextromethorphan.

brand name

Benylin DM (Parke-Davis); Dextromethorphan Hydrobromide OROS Tablets (Ciba-Geigy); Drixoral Cough (Schering-Plough HealthCare); PediaCare 1 (McNeil Consumer); Romilar (Hoffmann-LaRoche-International); St. Joseph Cough Syrup (Schering-Plough HealthCare).

Biological Activity

Non-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent.

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