Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Pharmaceutical intermediates >  3'-fluoro-3'-deoxyadenosine

3'-fluoro-3'-deoxyadenosine

Basic information Safety Supplier Related

3'-fluoro-3'-deoxyadenosine Basic information

Product Name:
3'-fluoro-3'-deoxyadenosine
Synonyms:
  • 3'-fluoro-3'-deoxyadenosine
  • (2R,3S,4S,5R)-2-(6-Amino-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol
  • 3'-F-3'-rA
  • Adenosine, 3'-deoxy-3'-fluoro-
  • 3'-fluoro-3'-deoxyadenosine
  • 3’-Deoxy-3’-fluoro adenosine
CAS:
75059-22-2
MF:
C10H12FN5O3
MW:
269.23
Mol File:
75059-22-2.mol
More
Less

3'-fluoro-3'-deoxyadenosine Chemical Properties

Melting point:
211-212 °C
Boiling point:
628.6±65.0 °C(Predicted)
Density 
2.01±0.1 g/cm3(Predicted)
pka
12.45±0.70(Predicted)
InChI
InChI=1S/C10H12FN5O3/c11-5-4(1-17)19-10(7(5)18)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14)/t4-,5-,7-,10-/m1/s1
InChIKey
QCDAWXDDXYQEJJ-QYYRPYCUSA-N
SMILES
OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](O)[C@@H]1F
More
Less

3'-fluoro-3'-deoxyadenosine Usage And Synthesis

Uses

3'-deoxy-3'-fluoroadenosine can be used as pharmaceutical intermediates for pharmaceutical experimental research.

Biological Activity

3'-Fluoro-3'-deoxyadenosine was active against a broad range of viruses, encompassing both DNA viruses [pox (vaccinia)], single-stranded (+) RNA viruses [picorna (polio, Coxsackie B), toga (sindbis, Semliki Forest)] and double-stranded RNA viruses (reo). Its antiviral activity spectrum, 3'-fluoro-3'-deoxyadenosine, clearly differed from those adenosine analogs known as inhibitors of S-adenosylhomocysteine hydrolase. 3'-Fluoro-3'-deoxyadenosine also proved effective in vivo in inhibiting tail lesion formation in mice inoculated intravenously with vaccinia virus[1].

References

[1] A. Van Aerschot. “Synthesis and antiviral activity evaluation of 3′-fluoro-3′-deoxyribonucleosides: broad-spectrum antiviral activity of 3′-fluoro-3′-deoxyadenosine.” Antiviral research 12 3 (1989): Pages 133-150.

3'-fluoro-3'-deoxyadenosineSupplier

Zhengzhou Granlen Sciences, ltd. Gold
Tel
0371-85513397
Email
info@granlen.com
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Email
info@chemlin.com.cn
T&W GROUP
Tel
021-61551611 13296011611
Email
contact@trustwe.com
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Email
info@sagechem.com
Nanjing Baifuli Technology Co., Ltd.
Tel
25-25-58740604 15951658055
Email
sales@unisyn.cn