pseudolycorine
pseudolycorine Basic information
- Product Name:
- pseudolycorine
- Synonyms:
-
- PSEUDOLYCORIN
- 3,12-Didehydro-9-methoxygalanthan-1α,2β,10-triol
- Galanthan-1,2,10-triol, 3,12-didehydro-9-methoxy-, (1-alpha,2-beta)- (9ci)
- Psi-lycorine
- 1H-Pyrrolo[3,2,1-de]phenanthridine-1,2,10-triol, 2,4,5,7,11b,11c-hexahydro-9-methoxy-, (1S,2S,11bS,11cS)-
- CAS:
- 29429-03-6
- MF:
- C16H19NO4
- MW:
- 289.33
- Mol File:
- 29429-03-6.mol
pseudolycorine Chemical Properties
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
pseudolycorine Usage And Synthesis
Description
Pseudolycorine can halt HeLa cell growth at 10-1 mM or lower concentrations, it at its growth inhibitory concentrations blocks protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Pseudolycorine exhibits cytotoxic profiles against cancer cell lines. 3. Pseudolycorine and haemanthamine show good activity in in vitro assays against Trypanosoma brucei rhodesiense, T. cruzi and Plasmodium falciparum with IC50 values in the range of 3.66 uM or lower. 4. Pseudolycorine, primarily studied as a new antiviral agent , it also shows remarkable antileukemic activity.
Uses
Pseudolycorine is an Amaryllidaceae alkaloid with anticancer activity[1].
Definition
ChEBI: Pseudolycorine is a member of phenanthridines.
target
Antifection | DNA/RNA Synthesis
References
[1] Gwendoline Van Goietsenoven, et al. Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells. J Nat Prod. 2010 Jul 23;73(7):1223-7. DOI:10.1021/np9008255
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