C 1311
C 1311 Basic information
- Product Name:
- C 1311
- Synonyms:
-
- C 1311
- 5-((2-(Diethylamino)ethyl)amino)-8-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one
- XLS-002
- Symadex
- CUNDRHORZHFPLY-UHFFFAOYSA-N
- Symadex >=98% (HPLC)
- 6H-Imidazo[4,5,1-de]acridin-6-one, 5-[[2-(diethylamino)ethyl]amino]-8-hydroxy-
- CAS:
- 138154-39-9
- MF:
- C20H22N4O2
- MW:
- 350.41
- Mol File:
- 138154-39-9.mol
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C 1311 Chemical Properties
- Boiling point:
- 605.8±65.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL (clear solution; warmed)
- form
- powder
- pka
- 8.35±0.20(Predicted)
- color
- white to beige
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C 1311 Usage And Synthesis
Uses
C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe[1].
Biological Activity
Symadex is an FMS-like tyrosine kinase 3 (FLT3) and topoisomerase-II inhibitor; ABCG2 substrate; cell cycle modulator.
References
[1] Magdalena Hyzy, et al. Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells. Biochem Pharmacol. 2005 Mar 1;69(5):801-9. DOI:10.1016/j.bcp.2004.11.028
C 1311Supplier
CONIER CHEM AND PHARMA LIMITED
- Tel
- +8618523575427
- sales@conier.com
Energy Chemical
- Tel
- 021-58432009 400-005-6266
- marketing1@energy-chemical.com
Suzhou Meishi Biotechnology Co., Ltd.
- Tel
- 1173954148q
- meishipharma@126.com
Merck KGaA
- Tel
- 21-20338288
- ordercn@merckgroup.com
Biosynth Biological Technology (Suzhou) Co Ltd
- Tel
- 51288865780
- sales@biosynth.com
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