L-GLUTAMIC-3-13C ACID Chemical Properties

Melting point:

205 °C (dec.) (lit.)

form 

solid

optical activity

[α]25/D +31.0°, c = 2 in 5 M HCl

CAS Number Unlabeled

56-86-0

Safety Information

WGK Germany 

3

MSDS

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L-GLUTAMIC-3-13C ACID Usage And Synthesis

Uses

L-Glutamic acid-13C is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

IC 50

NMDA Receptor

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7. DOI:10.1016/0304-3940(77)90068-4

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