Perfluoropropionic acid Chemical Properties

Boiling point:

96-97 °C (lit.)

Density 

1.561 g/mL at 25 °C (lit.)

vapor density 

~5.6 (vs air)

vapor pressure 

~40 mm Hg ( 20 °C)

refractive index 

n20/D 1.284(lit.)

Flash point:

None

storage temp. 

Store below +30°C.

Water Solubility 

Soluble in water

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

0.38±0.10(Predicted)

form 

Liquid

color 

Clear colorless to slightly brown

Specific Gravity

1.561

Sensitive 

Hygroscopic

BRN 

1773387

Stability:

hygroscopic

Major Application

PFAS testing

InChI

1S/C3HF5O2/c4-2(5,1(9)10)3(6,7)8/h(H,9,10)

InChIKey

LRMSQVBRUNSOJL-UHFFFAOYSA-N

SMILES

OC(=O)C(F)(F)C(F)(F)F

CAS DataBase Reference

422-64-0(CAS DataBase Reference)

NIST Chemistry Reference

Pentafluoropropionic acid(422-64-0)

EPA Substance Registry System

Pentafluoropropionic acid (422-64-0)

Safety Information

Hazard Codes 

C

Risk Statements 

20-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

RTECS 

UF6475000

F 

3

Hazard Note 

Corrosive

TSCA 

TSCA listed

HazardClass 

8

PackingGroup 

III

HS Code 

29159080

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Inhalation
Eye Dam. 1
Met. Corr. 1
Skin Corr. 1B

Toxicity

LD10 orl-rat: 750 mg/kg GTPZAB10(3),13,66

MSDS

• Language:English Provider:Perfluoropropionic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Perfluoropropionic acid Usage And Synthesis

Chemical Properties

Perfluoropropionic acid (PFPrA[2]) or pentafluoropropionic acid is the perfluoroalkyl carboxylic acid with the formula CF3CF2CO2H. It is a clear colourless to slightly brown liquid that is strongly acidic and soluble in water and polar organic solvents.

Uses

Pentafluoropropionic acid is used as an efficient catalyst for the preparation of dibenzo[a, j] xanthenes by condensation reaction of beta-naphthol with aryl aldehydes.

Uses

Pentafluoropropionic acid (Perfluoropropionic acid) was used in the analysis of gentamicin with Gemini column by liquid chromatographic (LC) methods.

General Description

The kinetics of the reaction of pentafluoropropionic acid with fluorine atoms was studied.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion.When heated to decomposition it emits toxic fumes of Fí.

Synthesis

A cogeneration process of hexafluoroisopropyl methyl ether and pentafluoropropionic acid:

(1) weighing 32 g of methanol in a 250 mL round-bottomed flask, to which 8.1 g of sodium methanol was added and stirred until it was fully dissolved, to obtain a methanol solution of sodium methanol;

(2) weighing 31.6 g of perfluoro-2-methyl-2,3-epoxypentane in the methanol solution of sodium methanol from step 1), sealing the Round bottom flask, it will be placed in a cold bath at 0 ??, 700r/min stirring reaction for 2h, to get the product containing the mixture;

(3) the product of step 2) will be filtered to remove insoluble salts, to the filtrate to add deionized water to wash three times to remove methanol, aqueous wash solution after fractionation to take the lower layer of the liquid distillation, the purity of 99.5% of the hexafluoroisopropyl methyl ether and pentafluoropropionic acid Methyl pentafluoropropionate;

(4) add 400mL of sulfuric acid with a concentration of 1 mol/L to methyl pentafluoropropionate, stirring at 60??C for 3h, and distillate at the end of the reaction to obtain pentafluoropropionic acid with a purity of 99%.

This hexafluoroisopropyl methyl ether cogeneration process of pentafluoropropionic acid adopts methoxy alkali metal salt and perfluoro-2-methyl-2,3-epoxypentane as the main raw materials, and carries out ring-opening alkylation reaction under the condition of alcohol solvent to obtain hexafluoroisopropyl methyl ether and pentafluoropropionic acid at the same time, and avoids the problems of hexafluoroisopropanol as raw materials in the existing technology which is expensive, and dimethyl sulphate is a highly toxic alkylation reagent, and its The process route is simple, and both the main product and by-product have economic value, which is suitable for industrial application.

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