Dimethylamine hydrochloride Chemical Properties

Melting point:

170-173 °C(lit.)

Boiling point:

95.79°C (rough estimate)

Density 

0.8949 (rough estimate)

vapor pressure 

<0.1 hPa (25 °C)

refractive index 

1.4202 (estimate)

storage temp. 

Store below +30°C.

solubility 

H2O: soluble0.5g/10 mL

form 

Crystalline Powder or Crystals

color 

White to off-white

PH

5 (100g/l, H2O, 20℃)

Water Solubility 

3000 g/L (20 ºC)

Sensitive 

Hygroscopic

Merck 

14,3228

BRN 

3589311

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

IQDGSYLLQPDQDV-UHFFFAOYSA-N

LogP

-3.28

CAS DataBase Reference

506-59-2(CAS DataBase Reference)

EPA Substance Registry System

Methanamine, N-methyl-, hydrochloride (506-59-2)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36/37-37/39-36

WGK Germany 

1

RTECS 

IQ0220000

F 

3-9

TSCA 

Yes

HS Code 

29211190

Toxicity

LD50 in mice (g/kg): 1.21 i.v., 2.00 s.c. (Hazard); LC50 in mice (ppm): 7650 (48 hr), 4725 (14 day); in rats (ppm): 4540 (6 hr) (Steinhagen)

MSDS

• Language:English Provider:Dimethylammonium chloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Dimethylamine hydrochloride Usage And Synthesis

Description

Dimethylamine hydrochloride is the raw material of organic synthesis, the catalyzer of analysis as an acetylize, and the preparation of azoviolet and dimethylamine aqueous solution. Dimethylamine hydrochloride deoxidation is very capable, and corrodibility is vital, so be usually used in cleaning-type soldering flux. Preparation technology is for slowly splashing into hydrochloric acid in dimethylamine for tradition, and the speed that splashes into is no more than 15 ℃ with temperature, and pH=7-8 is limited. After the reaction finishes, activated carbon decolorizing is added, the filtrate is adjusted to pH=3-4 with hydrochloric acid, decompression is steamed water to the greatest extent, obtaining dimethylamine hydrochloride.

Chemical Properties

White, foliage-like crystals with a melting point of 171°C. Highly soluble in water, soluble in alcohol and chloroform, and insoluble in ether. Exhibits deliquescence.

Uses

Dimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, tramadol and amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde.

Uses

Dimethylamine hydrochloride is a precursor to several industrially significant compounds.

Uses

As accelerator in vulcanizing rubber, tanning, manufacture of detergent soaps, or attracting boll weevils to exterminate them. As reagent for Mg.

Preparation

Dimethylamine hydrochloride is obtained from the salt formation of dimethylamine and hydrochloric acid.

Application

Dimethylamine hydrochloride serves as a foundational material for organic synthesis and is utilized as a catalyst and magnesium reagent in acetylation analysis. It has been used in producing hexamethylmelamine-methyl-14C and in preparing standard solutions of methylamine (MA), dimethylamine (DMA), trimethylamine (TMA), and trimethylamine-N-oxide (TMAO) to assess the presence of methylamines and trimethylamine-N-oxide in particulate matter.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise the salt from hot CHCl3 or absolute EtOH. It also recrystallises from MeOH/ether solution. Dry it in a vacuum desiccator over H2SO4, then P2O5. Hygroscopic. [Beilstein 4 IV 132.]

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