1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Chemical Properties

Melting point:

147-149°C

Boiling point:

350.0±37.0 °C(Predicted)

Density 

1.351±0.06 g/cm3(Predicted)

pka

16.63±0.40(Predicted)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Usage And Synthesis

Mechanism of action

Although βCCE and other β-carbolines are not endogenous BZR ligands (vide supra) and are not currently approved for clinical use, they are used to characterize different GABAA/BZR subtypes (based on a and g subunit composition) and function (e.g., the partial agonist abecarnil) toward the discovery of anxioselective drugs. In this regard, the β-carboline ring system is planar in comparison to the boat conformation of the 1,4-benzodiazepines; thus, β-carbolines have been useful to extend structure–activity relationship information for the agonist, antagonist, and inverse agonist pharmacophores of the various GABAA/BZR subtypes.

Clinical Use

Several β-carbolines have approximately 10-fold higher affinity for the BZR when compared to diazepam. The ethyl ester of β-carboline-3-carboxylic acid (βCCE), identified in human urine extracts as an artifact of the extraction procedure, has very high affinity for the BZR.

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE(112037-78-2)Related Product Information

• N-(4-CHLORO-3-NITROPHENYL)-1-(TRIFLUOROMETHYL)-1,3,4,9-TETRAHYDRO-2H-BETA-CARBOLINE-, TECH
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