Hexamethylphosphorous triamide Chemical Properties

Melting point:

-44 °C

Boiling point:

48-50 °C/12 mmHg (lit.)

Density 

0.898 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.463(lit.)

Flash point:

73 °F

storage temp. 

Inert atmosphere,2-8°C

form 

Liquid

pka

8.03±0.70(Predicted)

color 

Clear colorless to slightly yellow

Specific Gravity

0.8980

Water Solubility 

REACTS

Sensitive 

Moisture Sensitive

BRN 

906778

Stability:

Stable. Highly flammable - note low flash point. Incompatible with oxidizing agents.

InChIKey

XVDBWWRIXBMVJV-UHFFFAOYSA-N

CAS DataBase Reference

1608-26-0(CAS DataBase Reference)

NIST Chemistry Reference

Phosphorous triamide, hexamethyl-(1608-26-0)

EPA Substance Registry System

Phosphorous triamide, hexamethyl- (1608-26-0)

Safety Information

Hazard Codes 

T,Xi,Xn,F

Risk Statements 

45-46-10-40-36/37/38

Safety Statements 

53-45-36/37/39-26-16-37/39-36

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

RTECS 

TH3390000

F 

10

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29299000

MSDS

• Language:English Provider:Tris(dimethylamino)phosphine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Hexamethylphosphorous triamide Usage And Synthesis

Chemical Properties

colourless liquid

Uses

Hexamethylphosphorous triamide can be combination with CCl4 for the conversion of hydroxyl groups to the corresponding chlorides; hydroxyl group activation; dehydrations.

Uses

Hexamethylphosphorous triamide can be uesd in suzuki reaction.

Uses

Hexamethylphosphorous triamide can be widely used in industry, with applications such as being a flame retardant for building materials to a phosphorylating agent in synthetic chemistry. It is a classified carcinogen.

reaction suitability

reagent type: ligand
reaction type: Reductions
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand
reaction type: Wittig Reaction

Purification Methods

It may contain more than 1% of phosphoric triamide. The yellow oil is first distilled at atmospheric pressure, then under reduced pressure and stored under N2. It is air sensitive, TOXIC, and should not be inhaled. It is absorbed through the skin. [Mark Org Synth Coll Vol V 602 1973, Beilstein 4 IV 274.]

Hexamethylphosphorous triamide(1608-26-0)Related Product Information

• Triphenylphosphine
• Triphenylphosphine oxide
• 4-Dimethylaminobenzaldehyde
• 3-Dimethylaminopropylamine
• Tris(hydroxymethyl)aminomethane
• Tricine
• BIS-Tris
• Dimethylsulfamoyl chloride
• Tributylphosphine
• Tris(4-nitrophenyl)amine
• TRIS(DIETHYLAMINO)PHOSPHINE
• Tris(2-methyl-1-aziridinyl)phosphine oxide
• HEXA-N-PROPYL PHOSPHOROUS TRIAMIDE
• TEPA
• Trimorpholinophosphine oxide
• Azidotris(diethylamino)phosphonium bromide
• Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate
• Phosphine