PSEUDOJERVINE Chemical Properties

Melting point:

300-301° (dec)

alpha 

D25 -133° (c = 0.48 in 1:3 ethanol-chloroform)

Boiling point:

643.44°C (rough estimate)

Density 

1.1485 (rough estimate)

refractive index 

1.5960 (estimate)

pka

12.91±0.70(Predicted)

PSEUDOJERVINE Usage And Synthesis

Description

This alkaloid has been found in both Veratrum album and V. viride Ait. It crystallizes from EtOH in hexagonal tablets and has [α]²⁰_D - 139° (CHC13). The hydrochloride dihydrate has m.p. 254-6°C (dry, dec.); the sulphate is also crystalline but the aurichloride is amorphous. Poethke has shown that the alkaloid is a secondary base, gives a nitro so derivative, m.p. 261°C, and contains five replaceable hydrogen atoms. On boiling with dilute HCl it is hydrolyzed to (+)- glucose and isojervine, an isomer of jervine. This latter base crystallizes with solvent, e.g. the CHC13 adduct softens at 135-1500 C; the crystallizate with EtOH has m.p. 114-6°C (dec.) and that with Me2CO has m.p. 110-4°C; [α]²⁰_D - 32° (EtOH).

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Veratrum nigrum L.

Uses

Pseudojervine is a glycoalkaloid with a feeble inhibition activity against platelet aggregation[1].

Definition

ChEBI: Pseudojervine is a steroid saponin.

References

Wright, Luff., J. Chem. Soc., 35,405,421 (1879)
Salzberger., Arch. Pharm., 228,462 (1890)
Poethke., ibid, 275,357,571 (1937)
Poethke., ibid, 276, 170 (1938)
Jacobs, Craig.,J. Biol. Chem., 155,564 (1944)

PSEUDOJERVINE(36069-05-3)Related Product Information

• Cevadine
• veratramine
• 3,4-Dimethoxybenzoic acid
• PROTOVERATRINE A
• VERATROSINE
• 3,4-Dimethoxybenzyl alcohol
• CYCLOPAMINE
• VERATRIDINE
• (Z)-6-HENICOSEN-11-ONE
• 3,7-DIMETHYL-2-METHYLENE-OCT-6-ENAL
• 3-(ALLYLOXY)PIPERIDINE
• 2-Isopropyl-5-methyl-2-hexenal
• 3-(3-ALLYL)-5-HEXEN-1-AL
• JERVINE
• PSEUDOJERVINE