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Tilorone dihydrochloride

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Tilorone dihydrochloride Basic information

Product Name:
Tilorone dihydrochloride
Synonyms:
  • TILORONE HYDROCHLORIDE
  • 2,7-BIS[2-(DIETHYLAMINO)ETHOXY]-9-FLUORENONE DIHYDROCHLORIDE
  • TILORONE 2HCL
  • 2,7-Bis-deae-fluorenone
  • 9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-, dihydrochloride
  • Deae-f
  • Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-, dihydrochloride
  • Rmi 10008da
CAS:
27591-69-1
MF:
C25H36Cl2N2O3
MW:
483.47
Product Categories:
  • C15 to C38
  • Carbonyl Compounds
  • Chemical Synthesis
  • Ketones
  • Organic Building Blocks
  • strong recommend
  • Fluorene series
  • Fused Ring Systems
  • Building Blocks
Mol File:
27591-69-1.mol
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Tilorone dihydrochloride Chemical Properties

Melting point:
230-233 °C(lit.)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Methanol (Slightly)
form 
Solid
color 
Orange
Merck 
14,9440
InChIKey
BSVYJQAWONIOOU-UHFFFAOYSA-N
CAS DataBase Reference
27591-69-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38-40
Safety Statements 
7-22-26-37/39
WGK Germany 
3
RTECS 
LL9000000
HS Code 
2922.39.4500
Toxicity
LD50 in mice, rats (single dose): 959, 852 mg/kg orally; 145, 244 mg/kg i.p. (Krueger, Mayer)

MSDS

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Tilorone dihydrochloride Usage And Synthesis

Description

Tilorone is an orally active, antiviral compound that induces interferon production and is reported to have antitumor, anti-inflammatory, and neuroprotective actions. With chronic administration, tilorone induces lysosomal glycosaminoglycan storage, rendering glycosaminoglycans resistant to enzymatic degradation.

Chemical Properties

Orange-yellow crystalline powder

Uses

Tilorone dihydrochloride is an orally active, interferon-inducing antiviral agent.

Uses

Tilorone dihydrochloride was used to study the interaction of drugs with synthetic self-complementary DNA by SPR (Surface Plasmon Resonance).

Definition

ChEBI: Tilorone dihydrochloride is the dihydrochloride salt of tilorone. It is used as an antiviral drug to treat influenza, herpes infection, viral hepatitis, acute respiratory viral infections and SARS. It has a role as an anti-inflammatory agent, an antineoplastic agent, an interferon inducer, a nicotinic acetylcholine receptor agonist and an antiviral drug. It contains a tilorone(2+).

brand name

Tilorone is INN.

General Description

Effect of tilorone dihydrochloride on the changes of transmembrane potential of mitochondrial membranes of the isolated rat hepatocytes has been investigated. Tilorone dihydrochloride is an orally active, interferon-inducing antiviral agent.

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