3-Hydroxy-2-nitropyridine Chemical Properties

Melting point:

69-71 °C (lit.)

Boiling point:

256.56°C (rough estimate)

Density 

1.5657 (rough estimate)

refractive index 

1.4800 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

form 

Crystalline Powder

pka

0.31±0.22(Predicted)

color 

Yellow

BRN 

124473

InChIKey

QBPDSKPWYWIHGA-UHFFFAOYSA-N

CAS DataBase Reference

15128-82-2(CAS DataBase Reference)

EPA Substance Registry System

3-Hydroxy-2-nitropyridine (15128-82-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

RTECS 

UU7715000

Hazard Note 

Irritant

HS Code 

29333990

Toxicity

mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04089,

MSDS

• Language:English Provider:3-Hydroxy-2-nitropyridine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-Hydroxy-2-nitropyridine Usage And Synthesis

Chemical Properties

yellow crystalline powder

Uses

3-Hydroxy-2-nitropyridine may be used in the synthesis of novel sulfonates that are potent inhibitors of cell proliferation and tubulin polymerization.

Preparation

Synthesis of 3-hydroxy-2-nitropyridine: add 10g of 3-hydroxypyridine, 80ml of ethyl acetate, 4.2g of KNO3 and 21ml of acetic anhydride into a 250mL three-necked flask, and heat at 45°C with magnetic stirring After the reaction is completed, it is cooled to room temperature, filtered with suction, washed with a small amount of ethyl acetate for 1 to 2 times, the filtrate is taken to adjust the pH to neutrality with saturated NaOH solution, and extracted with ethyl acetate for 3 to 4 times. , take the extract and add activated carbon and heat under reflux for 1 hour, cool and filter, take the filtrate, dry with anhydrous magnesium sulfate, filter, concentrate on a rotary evaporator, and dry in a drying oven. 11.9 g of 3-hydroxy-2-nitropyridine was obtained with a yield of 81%.

3-Hydroxy-2-nitropyridine(15128-82-2)Related Product Information

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• 2-HYDROXY-4-NITROPYRIDINE,2-HYDROXY-4-NITROPYRIDINE 97%,2-Hydroxy-4-nitropyridine97%
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• 3-CHLORO-2-HYDROXY-5-NITROPYRIDINE
• 2-Bromo-6-hydroxy-3-nitropyridine