Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Antibiotics >  Penicillins drugs >  Sulbenicillin sodium

Sulbenicillin sodium

Basic information Safety Supplier Related

Sulbenicillin sodium Basic information

Product Name:
Sulbenicillin sodium
Synonyms:
  • alpha-sulfobenzylpenicillindisodium
  • sulpelin
  • SULBENICILLIN DISODIUM SALT
  • SULBENICILLIN SODIUM
  • disodium (2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(r)-2-phenyl-2-sulfonatoacetamido]-4-thia-azabicyclo[3.2.0]heptane-2-carboxylate
  • disodium [2S-(2alpha,5alpha,6beta)]-3,3-dimethyl-7-oxo-6-(phenylsulphonatoacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenyl-2-sulfoacetamido)-, disodium salt (8CI)
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylsulfoacetyl)amino]-, disodium salt, (2S,5R,6R)- (9CI)
CAS:
28002-18-8
MF:
C16H16N2Na2O7S2
MW:
458.42
EINECS:
248-769-3
Product Categories:
  • antibiotic
  • API
  • 28002-18-8
Mol File:
28002-18-8.mol
More
Less

Sulbenicillin sodium Chemical Properties

storage temp. 
Inert atmosphere,Room Temperature
Water Solubility 
Water: 250 mg/mL (545.35 mM)
CAS DataBase Reference
28002-18-8(CAS DataBase Reference)
More
Less

Sulbenicillin sodium Usage And Synthesis

Originator

Lillacillin,Takeda,Japan,1973

Definition

ChEBI: Sulbenicillin disodium is an organic sodium salt. It contains a sulbenicillin(2-).

Manufacturing Process

To a suspension of 1.08 parts by weight of 6-aminopenicillanic acid in 8 parts by volume of water is added 1.48 parts by weight of sodium bicarbonate. After the mixture is dissolved, a solution of 1.18 parts by weight of α-sulfophenylacetyl chloride in 10 parts by volume of diethylether is gradually added thereto. The mixture is stirred at a temperature in the neighborhood of 0°C for 1 hour. The aqueous layer is washed twice with 10 parts by volume of portions of ether and adjusted to pH 1.2 with cation exchange resin of polystyrene sulfonic acid type under constant cooling. Then the solution is washed twice with 15 parts by volume of portions of ethyl acetate, followed by extraction twice with 15 parts by volume of portions of n-butanol. The extracts are combined and washed twice with 15 parts by volume of portions of water and, then, extracted with an aqueous solution of sodium bicarbonate. The extract is adjusted to pH 6.5, washed with ether and lyophilized to give the sodium salt of α-sulfobenzylpenicillin. Yield is 1.2 parts by weight.

Therapeutic Function

Antibacterial

Sulbenicillin sodiumSupplier

Chongqing Fuan Pharmaceutical Co., Ltd Gold
Tel
13962610789
Email
sales@fapharm.com
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Email
buy@fortunachem.com
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Email
shyysw007@163.com
AILY INTL CHEMICAL CORP LTD
Tel
025-83208295 18913388297