2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Chemical Properties

Melting point:

109-110 °C

Boiling point:

450.2±45.0 °C(Predicted)

Density 

1.533

vapor pressure 

0-0Pa at 20-25℃

storage temp. 

2-8°C(protect from light)

solubility 

DMSO (Sparingly), Methanol (Slightly)

form 

Solid

color 

Pale Yellow

InChI

InChI=1S/C18H14FIS/c1-12-2-7-16(20)10-14(12)11-17-8-9-18(21-17)13-3-5-15(19)6-4-13/h2-10H,11H2,1H3

InChIKey

MGXZKAYHSITHMW-UHFFFAOYSA-N

SMILES

C1(C2=CC=C(F)C=C2)SC(CC2=CC(I)=CC=C2C)=CC=1

LogP

7.5 at pH7

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Usage And Synthesis

Chemical Properties

Pale Yellow Solid.

Uses

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene is an antidiabetic agent and a Canagliflozin (C175190) intermediate. Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and a candidate for the treatment of type 2 diabetes and obesity.

Synthesis

2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene (100 g; cf. WO 2005/012326) was dissolved in toluene (300 mL) at room temperature and under nitrogen atmosphere. To this solution, sodium iodide (83 g), cuprous(I) iodide (2.64 g), N,N'-dimethylethylenediamine (2.94 mL) and diethylene glycol dimethyl ether (50 mL) were added sequentially. The reaction mixture was heated to reflux temperature and stirred continuously for 36 hours. Upon completion of the reaction, ethyl acetate (300 mL) was added to the mixture at 40 °C and filtered through a filter pre-coated with activated carbon. The filtrate was washed and concentrated. The resulting residue was suspended in methanol (426 mL) at reflux temperature for 75 minutes. Subsequently, the suspension was cooled to 25 °C and stirring was continued for 1 hour. The precipitate was collected by filtration, washed with methanol and dried under vacuum at 50 °C to afford 2-(5-iodo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene (94.9 g) in white crystalline form. The mass spectrum (APCI) showed a m/z of 409 (M + H); the melting point was 109-110°C. The crystal was found to have the following properties.

References

[1] Patent: WO2009/35969, 2009, A1. Location in patent: Page/Page column 77
[2] Patent: US2010/99883, 2010, A1. Location in patent: Page/Page column 43
[3] Patent: US2016/228375, 2016, A1. Location in patent: Paragraph 0097; 0098

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene(898566-17-1)Related Product Information

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