LAZABEMIDE Chemical Properties

Boiling point:

397.4±37.0 °C(Predicted)

Density 

1.286±0.06 g/cm3(Predicted)

storage temp. 

room temp

solubility 

DMSO: ≥22mg/mL

form 

powder

pka

12.90±0.46(Predicted)

color 

white to tan

InChI

1S/C8H10ClN3O.H2O/c9-6-1-2-7(12-5-6)8(13)11-4-3-10;/h1-2,5H,3-4,10H2,(H,11,13);1H2

InChIKey

JYWYNPKXSLPWGV-UHFFFAOYSA-N

SMILES

O.NCCNC(=O)c1ccc(Cl)cn1

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

WGK Germany 

3

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2

LAZABEMIDE Usage And Synthesis

Chemical Properties

Lazabemide Monohydrochloride: C8Hl0ClN3O?HCl.[103878-83-7]. Crystallized from methanol-ether, melting point 193-195°C. Partition coefficient (n-octanol pulse): about 0.1. pKa 8.9. acute toxicity LD50 mice (mg/kg): 1000~2000 orally.

Uses

Treatment of Alzheimer’s disease.

Uses

Lazabemide hydrate may be used in cell signaling studies.

brand name

Tempium (Hoffmann-LaRoche).

Biochem/physiol Actions

Lazabemide is effective in treatment of Alzheimer′s disease and in combination with nicotine replacement therapy aids in smoking cessation.

LAZABEMIDE(103878-84-8)Related Product Information

• PHENYLENDIAMINE
• Tetramethrin
• Lenalidomide
• LAZABEMIDE
• 5-Chloropyridine-2-carboxamide
• PYRIDINE-2-CARBOXYLIC ACID (2-AMINO-ETHYL)-AMIDE
• N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid
• 1-(5-CHLOROPYRIDIN-2-YL)METHANAMINE
• 5-CHLORO-2-FORMYLPYRIDINE