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2'-C-Methyluridine

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2'-C-Methyluridine Basic information

Product Name:
2'-C-Methyluridine
Synonyms:
  • 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
  • Uridine, 2'-C-Methyl-
  • 2'-C-Methyl-1-β-D-ribofuranosyluracil
  • 2'-C-Methyluridine
  • 1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • 1-((2R,3R,4R,5R)-TETRAHYDRO-3,4-DIHYDROXY-5-(HYDROXYMETHYL)-3-METHYLFURAN-2-YL)PYRIMIDINE-2,4(1H,3H)-DIONE
  • EOS-61181
  • 1-(2-C-Methyl-β-D-ribofuranosyl)uracil
CAS:
31448-54-1
MF:
C10H14N2O6
MW:
258.23
Mol File:
31448-54-1.mol
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2'-C-Methyluridine Chemical Properties

Melting point:
110-112 °C
Density 
1.572
storage temp. 
2-8°C
form 
powder to crystal
pka
9.39±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C10H14N2O6/c1-10(17)7(15)5(4-13)18-8(10)12-3-2-6(14)11-9(12)16/h2-3,5,7-8,13,15,17H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,10-/m1/s1
InChIKey
NBKORJKMMVZAOZ-VPCXQMTMSA-N
SMILES
OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@](C)(O)[C@@H]1O
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Safety Information

HS Code 
2940.00.6000
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2'-C-Methyluridine Usage And Synthesis

Applications

There are two main applications of 2'-C-methyluridine, which are targeted at hepatitis C and leukemia.2′-C-methyluridine is one of the key intermediates in the synthesis of nucleoside anti-hepatitis C and anti-leukemia drugs.

Uses

A 2’-C-Me branched C-nucleoside that shows HCV polymerase inhibitory activity.

Uses

A 2’C-Me branched C-nucleoside that shows HCV polymerase inhibitory activity.

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