ELOCALCITOL
ELOCALCITOL Basic information
- Product Name:
- ELOCALCITOL
- Synonyms:
-
- ELOCALCITOL
- BXL 628
- (1R,3E,5S)-3-[(2E)-2-[(3aS,7aS)-1-[(E,2S)-6-ethyl-6-hydroxyoct-4-en-2-yl]-7a-methyl-3a,5,6,7-tetrahydro-3H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylidenecyclohexan-1-ol
- Ellocalciferol
- Cyclohexanol, 3-[(2E)-2-[(3aS,7aS)-1-[(1S,3E)-5-ethyl-5-hydroxy-1-methyl-3-hepten-1-yl]-3,3a,5,6,7,7a-hexahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylene-, (1R,3Z,5S)-
- Ro 26-9228
- CAS:
- 199798-84-0
- MF:
- C29H43FO2
- MW:
- 442.65
- Mol File:
- 199798-84-0.mol
ELOCALCITOL Chemical Properties
- Boiling point:
- 568.3±50.0 °C(Predicted)
- Density
- 1.05±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Ethanol:20.0(Max Conc. mg/mL);45.18(Max Conc. mM)
- form
- A crystalline solid
- pka
- 14.04±0.40(Predicted)
ELOCALCITOL Usage And Synthesis
Description
BXL-628 is an analog of vitamin D3 that has diverse biological activities. It increases death of androgen-stimulated human benign prostatic hyperplasia (BPH) cells via induction of apoptosis in a dose-dependent manner. In vivo, BXL-628 completely inhibits androgen-stimulated prostate overgrowth in a rat model of BPH. It reduces expression of IL-13 and IgE/mast cell-derived protease 1 (MMCP1) and decreases edema and leukocyte infiltration in the bladder wall in a mouse model of allergen-induced interstitial cystitis. BXL-628 also reduces the number of adherent endometrial stromal cells and decreases the total weight of endometrial lesions in a mouse model of endometriosis. Formulations containing BXL-628 are under clinical investigation for the treatment of BPH.
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