Methyl trans-4-AMinocyclohexanecarboxylate Hydrochloride Chemical Properties

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

color 

White to Almost white

Water Solubility 

Soluble in water.

InChI

InChI=1/C8H15NO2.ClH/c1-11-8(10)6-2-4-7(9)5-3-6;/h6-7H,2-5,9H2,1H3;1H/t6-,7-;

InChIKey

NHAYDXCUCXRAMF-MEZFUOHNNA-N

SMILES

C([C@@H]1CC[C@@H](N)CC1)(=O)OC.Cl |&1:1,4,r|

Safety Information

HS Code 

2922498590

Methyl trans-4-AMinocyclohexanecarboxylate Hydrochloride Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

Methyl trans-4-aminocyclohexanecarboxylate hydrochloride is generally used as a intermediate in pharmaceutical and chemical research.

Reactions

Methyl trans-4-AMinocyclohexanecarboxylate Hydrochloride can react with strong oxidizing agents.

Hazard

Methyl trans-4-AMinocyclohexanecarboxylate Hydrochloride can cause serious eye damage/eye irritation.

Synthesis

(Trans)-4-aminocyclohexanecarboxylic acid (200 mg, 1.40 mmol) was suspended in MeOH (5.5 mL) and cooled to -10 ℃. To this was added SOCl2 (204 μL, 2.79 mmol) dropwise, and the mixture was stirred for 15 minutes. The reaction mixture was warmed to ambient temperature for 15 minutes, followed by heating at reflux for 1 hour. After cooling, the mixture was concentrated to afford Methyl trans-4-AMinocyclohexanecarboxylate Hydrochloride (260 mg, 96.1 % yield).

References

[1] Patent: WO2011/6074, 2011, A1. Location in patent: Page/Page column 95

Methyl trans-4-AMinocyclohexanecarboxylate Hydrochloride(61367-07-5)Related Product Information

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