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cis-4-Hydroxy-L-proline

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cis-4-Hydroxy-L-proline Basic information

Product Name:
cis-4-Hydroxy-L-proline
Synonyms:
  • L-ALLO-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID
  • L-ALLO-4-HYDROXY-2-PYRROLIDINECARBOXYLLIC ACID
  • L-ALLO-HYDROXYPROLINE
  • CIS-4-HYDROXY-L-PROLINE
  • CIS-L-4-HYDROXYPROLINE
  • CIS-HYP-OH
  • CIS-HYDROXYPROLINE
  • CHYP
CAS:
618-27-9
MF:
C5H9NO3
MW:
131.13
EINECS:
210-542-1
Product Categories:
  • Amino Acids
  • Biochemistry
  • Biological-modified Amino Acids
  • Chiral Compound
  • Amino Acids & Derivatives
  • Chiral Reagents
  • Pyrrole&Pyrrolidine&Pyrroline
  • Chiral reagent
  • Heterocycles
Mol File:
618-27-9.mol
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cis-4-Hydroxy-L-proline Chemical Properties

Melting point:
257 °C (dec.) (lit.)
alpha 
-59 º (c=2, H2O)
Boiling point:
242.42°C (rough estimate)
Density 
1.3121 (rough estimate)
refractive index 
-59 ° (C=2, H2O)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble
pka
2.14±0.40(Predicted)
form 
Powder
color 
White to beige
Water Solubility 
soluble
Merck 
14,4840
BRN 
81440
InChIKey
PMMYEEVYMWASQN-IMJSIDKUSA-N
CAS DataBase Reference
618-27-9(CAS DataBase Reference)
EPA Substance Registry System
L-Proline, 4-hydroxy-, (4S)- (618-27-9)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36/37/39-27-26
WGK Germany 
3
10
TSCA 
Yes
HS Code 
29339900

MSDS

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cis-4-Hydroxy-L-proline Usage And Synthesis

Chemical Properties

White to beige powder

Uses

Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.

Definition

ChEBI: L-Proline in which a hydrogen at the 4-position of the pyrrolidine ring is substituted by a hydroxy group (S-configuration).

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