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3-Fluoropyridine

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3-Fluoropyridine Basic information

Product Name:
3-Fluoropyridine
Synonyms:
  • Pyridine, 3-fluoro-
  • 3-FLUOROPYRIDINE
  • 3-Fluoroypyridine
  • 3-FLUOROPYRIDINE 98% (GC)
  • 3-Fluoropyridine,98%
  • 3-Fluoropyridine 98%
  • 3-Fluoropyridine, 99% 1GR
  • 3-Fluoropyridine,99%
CAS:
372-47-4
MF:
C5H4FN
MW:
97.09
EINECS:
206-755-4
Product Categories:
  • Building Blocks
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Heterocyclic Building Blocks
  • Heterocyclic Fluorinated Building Blocks
  • Other Fluorinated Heterocycles
  • Pyridine
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyridine series
  • Halides
  • Pyridines
  • Pyridines derivates
  • Fluorine series
  • alkyl Fluorine
  • Fluorin-contained pyridine series
  • Fluoropyridines
  • Halopyridines
  • C5
  • Heterocyclic Building Blocks
  • bc0001
Mol File:
372-47-4.mol
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3-Fluoropyridine Chemical Properties

Melting point:
251-254°C (dec.)
Boiling point:
107-108 °C (lit.)
Density 
1.13 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.472(lit.)
Flash point:
56 °F
storage temp. 
Inert atmosphere,Room Temperature
form 
Liquid
pka
pK1:2.97(+1) (25°C)
Specific Gravity
1.130
color 
Clear yellow
BRN 
105702
InChIKey
CELKOWQJPVJKIL-UHFFFAOYSA-N
CAS DataBase Reference
372-47-4(CAS DataBase Reference)
NIST Chemistry Reference
3-F-pyridine(372-47-4)
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Safety Information

Hazard Codes 
F,Xi,Xn
Risk Statements 
11-36/37/38-20/21/22
Safety Statements 
16-26-36/37/39-33-7/9
RIDADR 
UN 1993 3/PG 2
WGK Germany 
3
Hazard Note 
Flammable/Irritant
HazardClass 
3
PackingGroup 
II
HS Code 
29333990

MSDS

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3-Fluoropyridine Usage And Synthesis

Chemical Properties

clear, colorless to yellow liquid.

Uses

3-Fluoropyridine was used in the synthesis of 3-halopyridin-4-yl-boronic acids and esters.

Preparation

A combination of CsF and HF provides a very reactive fluoride source and has shown faint promise with 3-chloropyridine giving 3-fluoropyridine in a very low yield.

General Description

3-Fluoropyridine is oxidized to corresponding N-oxides, which on treatment with hot acetic anhydride and hydrolysis yields 3-halo-2-pyridones. Microwave spectrum of 3-fluoropyridine has been investigated in the frequency range of 8-18GHz at dry ice temperature. Deprotonation of 3-fluoropyridine with Bu3MgLi in THF at -10°C has been studied.

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