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1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

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1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Basic information

Product Name:
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Synonyms:
  • 16:0 PC
  • 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE
  • 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
  • 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATIDYLCHOLINE
  • 1,2-DIHEXADECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
  • (R)-2,3-Bis(palMitoyloxy)propyl (2-(triMethylaMMonio)ethyl) phosphate
  • LIPOID PE 180/180-PEG
  • L-A-LECITHIN DIPALMITOYL
CAS:
63-89-8
MF:
C40H80NO8P
MW:
734.04
EINECS:
200-567-6
Product Categories:
  • Amines
  • Fatty Acid Derivatives & Lipids
  • Glycerols
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Phosphorylating and Phosphitylating Agents
  • Other
Mol File:
63-89-8.mol
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1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Chemical Properties

Melting point:
229-229.5 °C
alpha 
D23 +6.6° (c = 4.2 in 1:1 chloroform-methanol)
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Merck 
14,2477
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
KILNVBDSWZSGLL-KXQOOQHDSA-N
CAS DataBase Reference
63-89-8(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
10-21
HS Code 
29232000

MSDS

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1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Usage And Synthesis

Description

DPPC, also known as 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine, is a phospholipid containing the 16 carbon fatty acid/palmitic acid (16:0) at the sn-1 and sn-2 positions. It is commonly used in the generation of micelles, liposomes, and other types of artificial membranes. Due to the medium size of fatty acid chain, DLPC is used to form thinner membranes or lipid bilayers.

Chemical Properties

white powder

Uses

16:0 PC (DPPC) is suitable for use:

  • in vesicle preparation
  • as the main phospholipid component for all ultrasound contrast agents (UCA) formulations
  • as a component for microbubble preparation
  • in the preparation of lipid bilayers

Uses

16:0 PC (DPPC) has been used in the generation of thymoquinone (TQ) liposomes, gold nanorods and calcium chloride encapsulated liposomes and bilayers for biophysical studies.

Uses

1,2-dipalmitoyl-sn-glycero-3-phosphocholine is a major phospholipid constituent and primary surface tension lowering component of natural lung surfactant. Colfosceril Palmitate is used as pulmonary surfactant and diagnostic aid (fetal lung maturity).

Definition

ChEBI: A phosphatidylcholine 32:0 in which the 1- and 2-acyl groups are specified as hexadecanoyl (palmitoyl). A synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of pulmonary surfactants.

General Description

Phosphatidylcholine (PC) is a strong bilayer-forming lipid. It the most common phospholipid in mammalian membranes. It is also an important component of the mucosal layer of the colon.

Biochem/physiol Actions

Phosphatidylcholine (PC) functions as a surfactant within the mucus to form a hydrophobic surface to inhibit bacterial penetrance. It is used to treat fat embolism. Phosphatidylcholine lowers the levels of cholesterol and triglycerides.

Purification Methods

It has three crystalline forms 1, 2 and ' which change at 60-70o and at 229o, respectively. In order to obtain a fine powder, ~2 g are dissolved in CHCl3 (15mL) and pet ether (b 35-60o) is added; the solution is evaporated to dryness in vacuo at <20o and then dried at 0.1mm over CaCl2. [Baer & Maurukas J Am Chem Soc 74 158 1952, Baer & Kates J Biol Chem 185 615 1950, Beilstein 4 IV 1463.]

1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Preparation Products And Raw materials

Raw materials

1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINESupplier

Suzhou Highfine Biotech Co., Ltd Gold
Tel
0512-69209928 18306209922
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cathyjia@highfine.com
AVT(Shanghai) Pharmaceutical Tech Co., Ltd. Gold
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15692161719
Email
avt013@avt-cn.com
Shochem(Shanghai)Co.,Ltd Gold
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+86-021-51783479 +86-13816874662
Email
info@shochem.com
Suzhou Zehou Biotechnology Co. , Ltd. Gold
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0512-68716880 18075373931
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sales@growingchem.com
Suzhou Xingbei Pharmaceutical Technology Co., Ltd Gold
Tel
0512-0512-68437753 13861119411
Email
331723639@qq.com