4-BENZYLOXY-2-HYDROXYBENZALDEHYDE Chemical Properties

Melting point:

78-80°C

Boiling point:

165-175 °C(Press: 1 Torr)

Density 

1.238±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

7.80±0.10(Predicted)

Appearance

Light brown to brown Solid

Sensitive 

Air Sensitive

BRN 

982995

Safety Information

Hazard Codes 

Xi,N

Risk Statements 

36/37/38-50-43

Safety Statements 

26-36-61-36/37

HS Code 

2912210000

MSDS

• Language:English Provider:ALFA

4-BENZYLOXY-2-HYDROXYBENZALDEHYDE Usage And Synthesis

Synthesis

2,4-Dihydroxybenzaldehyde (3.0 g, 1.0 eq.) was dissolved in acetonitrile (220 mL), sodium bicarbonate (2.2 eq.) was added at room temperature and stirred for 45 minutes. Subsequently, benzyl bromide (1.1 eq.) was slowly added to the reaction system. The reaction mixture was heated to reflux and stirred continuously. Upon completion of the reaction, the reaction was quenched with deionized water (100 mL) and subsequently extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, washed with saturated saline (2 × 15 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent, to afford the crude product 4-phenylmethoxy-2-hydroxybenzaldehyde 12 as a white solid, which could be used in subsequent reactions without further purification.

References

[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 15, p. 4502 - 4510
[2] Synlett, 2011, # 11, p. 1605 - 1607
[3] Organic Process Research and Development, 2011, vol. 15, # 5, p. 1149 - 1162
[4] Tetrahedron Letters, 2013, vol. 54, # 31, p. 4121 - 4124
[5] Organic Letters, 2008, vol. 10, # 21, p. 5007 - 5010

4-BENZYLOXY-2-HYDROXYBENZALDEHYDE(52085-14-0)Related Product Information

• FUMARPROTOCETRARIC ACID
• LECANORIC ACID
• GYROPHORIC ACID
• 4'-BENZYLOXY-2'-HYDROXY-3'-METHYLACETOPHENONE
• ATRANORIN
• 4'-BENZYLOXY-2'-METHOXY-3'-METHYLACETOPHENONE
• EVERNIC ACID
• Salicylaldehyde
• STICTIC ACID
• KS 502
• LOBARIC ACID
• 4'-Benzyloxy-2'-hydroxyacetophenone
• 5-(benzyloxy)-2-hydroxybenzaldehyde
• 4-(Benzyloxy)-3-hydroxybenzaldehyde p-Toluenesulfonate
• 4-BENZYLOXY-3-HYDROXYBENZALDEHYDE
• PHYSODIC ACID
• 1-[4-(BENZYLOXY)-2-HYDROXYPHENYL]-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE
• 2,4-BIS(BENZYLOXY)BENZALDEHYDE