Sulfathiazole sodium Chemical Properties

storage temp. 

Store at -20°C

solubility 

H2O: soluble50mg/mL

form 

powder

color 

white to off-white

BRN 

3802297

Stability:

Hygroscopic

InChI

InChI=1S/C9H9N3O2S2.Na.H/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9;;/h1-6H,10H2,(H,11,12);;

InChIKey

PLYRQFRFHFKJLU-UHFFFAOYSA-N

SMILES

S(C1C=CC(N)=CC=1)(=O)(=O)NC1SC=CN=1.[NaH]

CAS DataBase Reference

144-74-1(CAS DataBase Reference)

EPA Substance Registry System

Benzenesulfonamide, 4-amino-N-2-thiazolyl-, monosodium salt (144-74-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25-23

WGK Germany 

2

RTECS 

WP2450000

F 

10

MSDS

• Language:English Provider:SigmaAldrich

Sulfathiazole sodium Usage And Synthesis

Description

Sulfathiazole sodium salt is a short-acting sulfa drug. It was a common oral and topical antibiotic until less toxic alternatives were discovered. It is no longer used in humans. Sulfathiazole is added to the diet of laboratory animals to inhibit folate formation by gut bacteria. This ensures that the animal′s only source of available folate is from their diet. Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Uses

Sulfathiazole sodium salt is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA). It can also be used in biological study of thermotherapy and sulfonamide antibiotics deciphered Cyanobacteria and Proteobacteria microbiome in huanglongbing-affected Citrus paradise and Citrus limon.

General Description

Chemical structure: sulfonamide

Biochem/physiol Actions

Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

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