SARPAGINE Chemical Properties

Melting point:

320°C

Boiling point:

450.55°C (rough estimate)

alpha 

D20 +54° (c = 0.5 in pyridine)

Density 

1.1396 (rough estimate)

refractive index 

1.5600 (estimate)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

10.24±0.40(Predicted)

Safety Information

RIDADR 

1544

HazardClass 

6.1(b)

PackingGroup 

III

SARPAGINE Usage And Synthesis

Description

This base has been isolated from Rauwolfia serpentina and is an isomer of Ajmalinine (q.v.). Pharmacologically it has between three and four times the effect of the total Rauwolfia alkaloids on isolated rabbit uterus and is very specific. In the cat, the blood pres~ure is lowered by 0.5-2.0 mgm per kilo body weight. The toxicity is low.

Definition

ChEBI: An indole alkaloid that is sarpagan bearing hydroxy groups at positions 10 and 17.

References

Bodendorf, Eder., Naturwis<., 40, 342 (1953)

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