2-(4-TERT-BUTYLPHENOXY)CYCLOHEXANOL Chemical Properties

Melting point:

93-95 °C

Boiling point:

365.7±42.0 °C(Predicted)

Density 

1.036±0.06 g/cm3(Predicted)

storage temp. 

Store at 4℃

solubility 

24.84mg/ml in DMSO, 24.84mg/ml in Ethanol

form 

powder

pka

14.60±0.40(Predicted)

color 

white to beige

EPA Substance Registry System

2-(p-tert-Butylphenoxy)cyclohexanol (1942-71-8)

Safety Information

Hazardous Substances Data

1942-71-8(Hazardous Substances Data)

2-(4-TERT-BUTYLPHENOXY)CYCLOHEXANOL Usage And Synthesis

Uses

tBPC is a selective positive allosteric modulator for human Y4 receptor (Y4R), which enhances the activation of Y4R in G protein signaling and arrestin3 recruitment[1].

Biological Activity

tBPC is a postitive allosteric modulator of the neuropeptide Y (NPY) Y4 receptor, which is predominantly expressed in the gastrointestinal tract and activated most strongly by pancreatic polypeptide (PP). tBPC was shown to potentiate Y4R activity in G-Protein signaling and arrestin3 recruitment and to potentiate the native PP response. tBPC was selective for Y4R over other Neuropeptide Y receptors and showed no effect on the efficacy (Emax) or potency (EC50) of the NPY signal response at the Y1, Y2, or Y5 receptors at 30 μM.

References

[1] Schubert M, et al., Identification and Characterization of the First Selective Y4 Receptor Positive Allosteric Modulator. J Med Chem. 2017 Sep 14;60(17):7605-7612. DOI:10.1021/acs.jmedchem.7b00976

2-(4-TERT-BUTYLPHENOXY)CYCLOHEXANOL(1942-71-8)Related Product Information

• Cyclohexanol
• Propargite