2,4,5-Trifluorobenzyl bromide Chemical Properties

Boiling point:

188.8±35.0 °C(Predicted)

Density 

1.71

refractive index 

1.5015

storage temp. 

Inert atmosphere,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow

Specific Gravity

1.71

Sensitive 

Lachrymatory

BRN 

8312091

InChI

InChI=1S/C7H4BrF3/c8-3-4-1-6(10)7(11)2-5(4)9/h1-2H,3H2

InChIKey

GAUXEYCSWSMMFZ-UHFFFAOYSA-N

SMILES

C1(CBr)=CC(F)=C(F)C=C1F

CAS DataBase Reference

157911-56-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,T

Risk Statements 

34-36-25

Safety Statements 

26-36/37/39-45-23-20

RIDADR 

1760

Hazard Note 

Corrosive/Lachrymatory

TSCA 

T

HazardClass 

8

PackingGroup 

II

HS Code 

29039990

MSDS

• Language:English Provider:2,4,5-Trifluorobenzyl bromide
• Language:English Provider:ALFA

2,4,5-Trifluorobenzyl bromide Usage And Synthesis

Chemical Properties

White low melting solid

Uses

2,4,5-trifluorobenzyl bromide is an important intermediate in the synthesis of Ensitrelvir (S-217622). Ensitrelvir is the latest oral drug developed by Japan's Shionogi Pharmaceutical Company to treat COVID-19. It is the first orally active, non-covalent, non-peptide SARS-CoV-23CL protease inhibitor.

Application

2,4,5-TRIFLUOROBENZYL BROMIDE is a useful research chemical.

Synthesis

Preparing 2,4,5-Trifluorobenzyl bromide, involves (a) carrying out esterification reaction on 2,4,5-trifluorobenzyl chloride and carboxylate to prepare 2,4,5-trifluorobenzyl ester, (b) hydrolyzing 2,4,5-trifluorobenzyl ester to prepare 2,4,5-trifluorobenzyl alcohol, and (c) brominating 2,4,5-trifluorobenzyl alcohol to prepare target product.

2,4,5-Trifluorobenzyl bromide(157911-56-3)Related Product Information

• Benzyltriethylammonium chloride
• Benzyl 2-bromoacetate
• Phosphorus oxybromide
• Benzyl bromide
• N,N-Dimethylbenzylamine
• Ethyl bromodifluoroacetate
• Sodium bromate
• Rocuronium bromide
• Ethidium bromide
• Benzyltrimethylammonium chloride
• Allyl bromide
• 1-Bromo-2,4,5-trifluorobenzene
• Benzyl chloride
• 4-Trifluoromethylbenzyl chloride
• Methyl bromide
• 2-Fluorobenzyl bromide
• α-Bromo-2,3,4,5,6-pentafluorotoluene
• 2,3,4,5-TETRAFLUOROBENZYL BROMIDE