N-BROMOACETAMIDE Chemical Properties

Melting point:

102-105°C

Boiling point:

127-130 °C(Press: 16 Torr)

Density 

1.7000 (rough estimate)

refractive index 

1.4740 (estimate)

storage temp. 

-20°C

solubility 

very slightly in Chloroform

pka

9.41±0.46(Predicted)

form 

powder

color 

white to yellow

Water Solubility 

Soluble in water.

Merck 

14,1398

BRN 

969346

CAS DataBase Reference

79-15-2(CAS DataBase Reference)

EPA Substance Registry System

N-Bromoacetamide (79-15-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

3261

WGK Germany 

3

F 

8

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29299090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

N-BROMOACETAMIDE Usage And Synthesis

Uses

Abolishes the rapid inactivation of membrane sodium- and potassium-ion channels.

Uses

N-bromoacetamide annihilates the rapid inactivation of membrane sodium-ion channels. Also functions in the kinetics of cardiac sodium ion channels.

General Description

White powder.

Air & Water Reactions

Soluble in water.

Reactivity Profile

N-BROMOACETAMIDE is sensitive to light, moisture, and heat. . N-BROMOACETAMIDE decomposes rapidly at elevated temperatures, in the presence of moisture and light.

Fire Hazard

Flash point data are not available for N-BROMOACETAMIDE, but N-BROMOACETAMIDE is probably combustible.

Purification Methods

A possible contaminant is CH3CONBr2. Recrystallise it from CHCl3/hexane (1:1, seed if necessary) or water and dry over CaCl2. It is a brominating agent. [Oliveto & Gerold Org Synth Coll Vol IV 104 1963.] Alternatively, dissolve it in the minimum volume of warm H2O (60o), then cool in an ice bath, collect the crystals and dry them in an anhydrous atmosphere, dissolve in Et2O, chill and evaporate till crystallisation. Dry the crystals in vacuo at 25o, then at 45o (m 108o). Crystallise from CHCl3 (m 103o). Estimate the available Br iodometrically [Buckles et al. J Org Chem 23 483 1958]. [Beilstein 2 H 181, 2 I 82, 2 II 180, 2 III 406, 2 IV 417.]

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