5-Bromo-2-chloropyridine
5-Bromo-2-chloropyridine Basic information
- Product Name:
- 5-Bromo-2-chloropyridine
- Synonyms:
-
- 5-BROMO-2-CHLOROPYRIDINE
- 2-CHLORO-5-BROMOPYRIDINE
- PYRIDINE, 5-BROMO-2-CHLORO-
- 3-Bromo-6-chloropyridine
- 5-bromo-2-chlorolpyridine
- 5-Bromo-2-chloropyridine, 98+%
- 5-BROMO-2-CHLOROPYRIDINE 98%
- 2-CHLORO-5-BROMOPYRIDINE 5-BROMO-2-CHLORO-PYRIDINE
- CAS:
- 53939-30-3
- MF:
- C5H3BrClN
- MW:
- 192.44
- EINECS:
- 700-053-6
- Product Categories:
-
- Pyridines derivates
- Halogenated
- Organohalides
- Bromopyridines
- Chloropyridines
- Halopyridines
- blocks
- Bromides
- Pyridines
- Boronic Acid
- C5Heterocyclic Building Blocks
- Halogenated Heterocycles
- Heterocyclic Building Blocks
- Variety of halogenated heterocyclic series
- compounds of pyridine
- Pyridine
- pyridine derivative
- Pyridine Series
- Pyridines, Pyrimidines, Purines and Pteredines
- Risdiplam
- bc0001
- Mol File:
- 53939-30-3.mol
5-Bromo-2-chloropyridine Chemical Properties
- Melting point:
- 65-69 °C (lit.)
- Boiling point:
- 208.1±20.0 °C(Predicted)
- Density
- 1.7783 (rough estimate)
- refractive index
- 1.5400 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -2.25±0.10(Predicted)
- form
- Crystalline Powder or Crystals
- color
- Off-white
- BRN
- 108887
- InChI
- InChI=1S/C5H3BrClN/c6-4-1-2-5(7)8-3-4/h1-3H
- InChIKey
- PEAOEIWYQVXZMB-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(Br)C=C1
- CAS DataBase Reference
- 53939-30-3(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39-36/37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- TSCA
- T
- HazardClass
- IRRITANT, IRRITANT-HARMFUL
- HS Code
- 29333990
MSDS
- Language:English Provider:5-Bromo-2-chloropyridine
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
5-Bromo-2-chloropyridine Usage And Synthesis
Chemical Properties
Light yellow Cryst
Uses
5-Bromo-2-chloropyridine may be used in the preparation of following compounds:
- Amino-2-chloropyridine via palladium-catalyzed amination.
- 5-Bromo-2-fluoropyridine via halogen-exchange reaction using anhydrous potassium fluoride.
- 2-Chloro-5-(2,5-dimethoxyphenyl)pyridine via Suzuki coupling with 2,5-dimethoxyphenylboronic acid.
Synthesis
6-Chloro-pyridin-3-ylamine was dissolved slowly with constant stirring in 48% HBr solution (50 mL) at r.t. and then the solution was cooled to -10 °C. A solution of sodium nitrite in cold water was added dropwise at -10 °C with constant stirring over 2 h, followed by a solution of copper (I) bromide in 48% HBr dropwise. The mixture was then stirred at r.t. until complete. The mixture was neutralized with sodium carbonate and extracted with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate, and concentrated. The residue was purified by column chromatography on silica gel (60-120 mesh) eluting with 1% ethyl acetate/petroleum ether to afford 5- bromo-2-chloropyridine.
5-Bromo-2-chloropyridine Preparation Products And Raw materials
Preparation Products
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5-Bromo-2-chloropyridine(53939-30-3)Related Product Information
- 1-Hexadecylpyridinium bromide
- 2-Chloro-5-chloromethylpyridine
- Clopidol
- 2-Chloro-5-fluoropyridine
- 2-Chloro-3-cyanopyridine
- 5-Amino-2-chloropyridine
- 2-chloro-5-cyanopyridine
- 3-Bromo-6-chloro-2-methylpyridine
- 6-Chloro-2-methyl-3-nitropyridine
- 2-Chloro-5-hydroxypyridine
- 2-CHLORO-5-METHOXYPYRIDINE
- 2-Chloro-5-nitropyridine
- 2-Chloro-5-iodopyridine
- 5-Bromo-2-chlorobenzoic acid
- pyridinium Chlorochromate
- Difluorochloromethane
- Bromine
- 2-Chloropyridine