Bis(2-oxo-3-oxazolidinyl)phosphinic chloride
Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Basic information
- Product Name:
- Bis(2-oxo-3-oxazolidinyl)phosphinic chloride
- Synonyms:
-
- bis(2-oxo-3-oxazolidinyl)-phosphinicchlorid
- PHOSPHORIC ACID BIS(2-OXOOXAZOLIDIDE) CHLORIDE
- N,N-BIS(2-OXO-3-OXAZOLIDINYL)PHOSPHINIC CHLORIDE
- N,N-BIS(2-OXO-3-OXAZOLIDINYL)PHOSPHONIC CHLORIDE
- N,N-BIS(2-OXO-3-OXAZOLIDINYL)PHOSPHORODIAMIDIC CHLORIDE
- Bis(2-oxo-3-oxazolid
- Phosphoric acid bi
- Phosphoric acid bis(2-oxooxazolidide) chloride(BOP-Cl)
- CAS:
- 68641-49-6
- MF:
- C6H8ClN2O5P
- MW:
- 254.56
- EINECS:
- 629-561-5
- Product Categories:
-
- Coupling Reagent
- Peptide coupling agents
- Biochemistry
- Condensation & Active Esterification
- Coupling Reactions (Peptide Synthesis)
- Peptide Synthesis
- Synthetic Organic Chemistry
- Mol File:
- 68641-49-6.mol
Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Chemical Properties
- Melting point:
- 191 °C (dec.)(lit.)
- Boiling point:
- 332.8±25.0 °C(Predicted)
- Density
- 1.71±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- slightly sol CH2Cl2, MeCN, THF, DMF; dec H2O
- pka
- -2.47±0.20(Predicted)
- form
- Crystalline Powder
- color
- White to off-white
- Water Solubility
- Hydrolyzes with water.
- Sensitive
- Moisture Sensitive
- BRN
- 3654596
- InChIKey
- KLDLRDSRCMJKGM-UHFFFAOYSA-N
- CAS DataBase Reference
- 68641-49-6(CAS DataBase Reference)
Safety Information
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45-27
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- RTECS
- SZ5871000
- F
- 10-21
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29349990
MSDS
- Language:English Provider:Bis(2-oxo-3-oxazolidinyl)phosphinic chloride
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Usage And Synthesis
Description
Bis(2-oxo-3-oxazolidinyl)phosphinic chloride is a reagent for activating carboxyl groups, converting acids to esters (including thioesters and phosphoesters), amides (including peptides and β-lactams), and anhydrides; reagent for kinetic resolution of racemic carboxylic acids and alcohols.
Chemical Properties
White solid
Uses
Bis(2-oxo-3-oxazolidinyl)phosphinic chloride was used in the preparation of hexadepsipeptide.
storage
Bis(2-oxo-3-oxazolidinyl)phosphinic chloride should store in a cool dry place under nitrogen to preclude contact with moisture and oxygen. Use only in a chemical fume hood. Wear suitable protective clothing and eye/face protection. Causes burns and is harmful if swallowed, inhaled, or absorbed through skin.
Purification Methods
the outcome of reactions can be greatly affected by the purity of the reagent; commercial samples may require to be washed with cold water and recrystallized from MeCN prior to use.
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Bis(2-oxo-3-oxazolidinyl)phosphinic chloride(68641-49-6)Related Product Information
- Phosphorus oxychloride
- Potassium chloride
- Choline chloride
- Phosphorus oxybromide
- Calcium chloride
- Sodium chloride
- Ammonium chloride
- Acetyl chloride
- Polyvinyl chloride
- Benzyl chloride
- Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester
- DIMETHYL-P-NITROPHENYLPHOSPHATE
- Methylene Chloride
- PARAOXON
- Ammonium carbonate additive
- AMMONIUM CARBAMATE
- BIS(DIMETHYLAMINO)PHOSPHORYL CHLORIDE
- BIS(DIMETHYLAMINO)CHLOROPHOSPHINE