5-FLUORO-1H-INDAZOLE Chemical Properties

Melting point:

119-125 °C

Boiling point:

274.9±13.0 °C(Predicted)

Density 

1.370±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

12.90±0.40(Predicted)

form 

solid

color 

Beige

CAS DataBase Reference

348-26-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933998090

5-FLUORO-1H-INDAZOLE Usage And Synthesis

Uses

5-Fluoro-1H-indazole(Indazole compound) or its physiologically acceptable derivative are respectively provided with the effect for inhibiting Rho kinase activity；It is thin with promoting The effect of born of the same parents' glucose consumption.

Synthesis

Step 2: Preparation of 5-fluoro-1H-indazole 1-(5-Fluoro-1H-indazol-1-yl)ethan-1-one (2.1 g, 11.8 mmol) was dissolved in a mixture of methanol (20 mL) and concentrated hydrochloric acid (10 mL), heated to 50 °C and maintained for 2 hours. Upon completion of the reaction, the reaction mixture was evaporated to dryness under reduced pressure. The residue was alkalized with saturated sodium bicarbonate solution and extracted with ethyl acetate, the organic phase was washed with water and concentrated to afford the target product 5-fluoro-1H-indazole (1.6 g, 100% yield). The purity was analyzed by LCMS and was 95.9%; m/z = 137.2.

References

[1] Patent: WO2015/193846, A1. Location in patent: Page/Page column 80
[1] Patent: , 2015, . Location in patent: Page/Page column 80

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