1-Methoxynaphthalene Chemical Properties

Melting point:

5 °C

Boiling point:

135-137 °C/12 mmHg (lit.)

Density 

1.09 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.621(lit.)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform, Methanol

form 

Oil

color 

Clear Colorless to Yellow

Specific Gravity

1.1

Water Solubility 

immiscible

BRN 

7748884

LogP

3.450

CAS DataBase Reference

2216-69-5(CAS DataBase Reference)

NIST Chemistry Reference

Naphthalene, 1-methoxy-(2216-69-5)

EPA Substance Registry System

Naphthalene, 1-methoxy- (2216-69-5)

Safety Information

Safety Statements 

23-24/25

RIDADR 

UN 3082 9/PG III

WGK Germany 

3

RTECS 

QJ9465500

TSCA 

Yes

HazardClass 

9

PackingGroup 

III

HS Code 

29093090

MSDS

• Language:English Provider:1-Methoxynaphthalene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
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1-Methoxynaphthalene Usage And Synthesis

Chemical Properties

1-Methoxynaphthalene is an isomer of methoxynaphthalene. It is clear light yellow to brown liquid that aroma is not as good as 2-methoxynaphthalene. Insoluble in water, soluble in ethanol, ether, benzene and chloroform.

Uses

1-Methoxynaphthalene is used in the study of peroxygenase activity of cytochrome c peroxidase. It is used as a precursor to synthesize prenyl naphthalene-ols, which shows antioxidative activity. It is also used in organic synthesis, pesticides, perfumes for making soaps, and film developers.

Preparation

1-Methoxynaphthalene can be obtained by methylating 1-naphthol, and the methylating reagent can be selected from methyl trifluoroacetate, dimethyl carbonate and dimethyl sulfate.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 675, 1991 DOI: 10.1016/S0040-4039(00)74857-X

General Description

1-Methoxynaphthalene, a methoxyphenolic compound, is a naphthalene derivative that finds application as a precursor for the preparation of pharmaceutical drugs, and also as a therapeutic agent.

Purification Methods

Steam distil the ether from alkaline solution. The distillate is extracted with Et2O. After drying (MgSO4) the extract and evaporating Et2O, the methyl naphthyl ether is then fractionated under reduced pressure from CaH2. The picrate has m 129.5-130.5o (from EtOH). [Beilstein 6 IV 4211.]

1-Methoxynaphthalene(2216-69-5)Related Product Information

• m-Anisyl alcohol
• POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE
• p-Anisidine
• Methoxydiethylborane
• p-Anisaldehyde
• 4-Methoxybenzoic acid
• Methoxyacetic acid
• Anisole
• (Trifluoromethoxy)benzene
• 1-Naphthyl acetate
• 4-METHOXY-2-NAPHTHYLAMINE P-TOLUENESULFONATE SALT
• 1-NAPHTHOXYACETIC ACID
• Propranolol hydrochloride
• Carbaryl
• 4-METHOXY-1-NAPHTHOL
• 1-NAPHTHYL BUTYRATE
• 4-Methoxy-1-naphthaldehyde
• 2-Methoxynaphthalene