AC-WEHD-CHO Chemical Properties

Boiling point:

1250.2±65.0 °C(Predicted)

Density 

1.434±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

H₂O: 1 mg/mL

form 

powder

pka

4.17±0.10(Predicted)

color 

white

Sequence

Ac-Trp-Glu-His-{Asp-Aldehyde}

Safety Information

Hazard Codes 

Xi

Risk Statements 

38

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

AC-WEHD-CHO Usage And Synthesis

Uses

Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM[1][2].

IC 50

Caspase-1: 56 pM (Ki)

References

[1] Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007. DOI:10.1016/j.chembiol.2010.07.011
[2] Rano TA, et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem Biol. 1997 Feb;4(2):149-55. DOI:10.1016/s1074-5521(97)90258-1

AC-WEHD-CHO(189275-71-6)Related Product Information

• AC-YVAD-CHO
• AC-ESMD-CHO
• AC-LYS(AC)-D-ALA-D-ALA-OH
• AC-WEHD-AMC
• AC-WEHD-PNA
• AC-TRP-GLU-HIS-ASP2RH110
• AC-WEHD-AFC
• AC-WEHD-CHO
• AC-TRP-GLU-HIS-ASP-AFC, TFA SALT