Basic information Safety Supplier Related

Etalocib

Basic information Safety Supplier Related

Etalocib Basic information

Product Name:
Etalocib
Synonyms:
  • Etalocib
  • LY293111
  • VML 295
  • YFIZRWPXUYFCSN-UHFFFAOYSA-N
  • LY293111 Exclusive
  • Benzoic acid, 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]-
  • 2-(3-(3-((5-Ethyl-4'-fluoro-2-hydroxy-[1,1'-biphenyl]-4-yl)oxy)propoxy)-2-propylphenoxy)benzoic acid
  • Etalocib(LY293111)
CAS:
161172-51-6
MF:
C33H33FO6
MW:
544.61
Mol File:
161172-51-6.mol
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Etalocib Chemical Properties

Melting point:
68-70 °C(Solv: acetonitrile (75-05-8))
Boiling point:
656.8±55.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:98.5(Max Conc. mg/mL);173.85(Max Conc. mM)
form 
Solid
pka
3.32±0.36(Predicted)
color 
White to off-white
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Etalocib Usage And Synthesis

Uses

Antineoplastic (inhibits formation of 5-LO, LTB4,LTC4, and thromboxane B2(TxB2); activates PPARγ nuclear receptors).

Uses

LY293111 is a leukotriene receptor antagonist and protect neurons from the sPLA2-IB-induced neuronal cell death independently of blocking their receptors.

Definition

ChEBI: LY293111 is an aromatic ether.

in vivo

Etalocib produces a dose-related inhibition of acute leukotriene B4-induced airway obstruction when administered i.v. (ED50=14 μg/kg) or p.o. (ED50=0.4 mg/kg)[2].
Etalocib (10 mg/kg) inhibits A23187-induced lung inflammatory changes at 1 h[2].
Etalocib (250 mg/kg/day, orally) inhibits growth of human pancreatic cancer xenografts in athymic mice[3].

Animal Model:Guinea pigs[2].
Dosage:1-10 mg/kg.
Administration:Orally once.
Result:A single 1 mg/kg oral dose inhibited excised lung gas volume increases by 76.7±7.1% (n=4, P<0.002) when given 8 h prior to leukotriene B4 challenge, and 28.6±20.3% (n=4, NS) when given 24 h before challenge.
Had no effect (10 mg/kg) on pulmonary gas trapping at 1 h or 2 h after A23187 challenge. However, at 4 h, the pulmonary gas trapping response was significantly less than that of vehicle-treated controls and not different from sham values. The 10 mg/kg dose inhibited A23187-induced lung inflammatory changes at 1 h, but was without effect at 2 h or 4 h after challenge.

IC 50

LTB4

EtalocibSupplier

Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Email
sales@boylechem.com
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Email
sales@letopharm.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Email
Sales@ATKchemical.com
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Email
psaitong@jm-bio.com
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