1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride Chemical Properties

Melting point:

198-205 °C

storage temp. 

Inert atmosphere,Room Temperature

Appearance

White to off-white Solid

Safety Information

HS Code 

2933599590

1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride Usage And Synthesis

Uses

1-(2,2,2-trifluoroethyl)piperazine dihydrochloride is a heterocyclic compound and can be used as a pharmaceutical synthesis intermediate.

Synthesis

The general procedure for the synthesis of 1-(2,2,2-trifluoroethyl)piperazine dihydrochloride from 1-Boc-4-(2,2,2-trifluoroethyl)piperazine was as follows: tert-butyl 4-(2,2,2-trifluoroethyl)piperazine-1-carboxylate (253 mg, 0.94 mmol) was dissolved in a dioxane solution (4.72 mL, 0.94 mmol) of methylene chloride (9 mL) and 4M hydrochloric acid. 18.9 mmol). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was concentrated under vacuum and co-evaporated three times with dichloromethane to afford 1-(2,2,2-trifluoroethyl)piperazine dihydrochloride (200 mg, 0.977 mmol, 100% yield) as a beige solid.

References

[1] Patent: WO2018/102453, 2018, A1. Location in patent: Paragraph 237
[2] Patent: WO2004/41829, 2004, A1. Location in patent: Page 75
[3] Patent: WO2006/46031, 2006, A1. Location in patent: Page/Page column 46-47

1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride(13349-91-2)Related Product Information

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• 1-(2,2,2-TRIFLUOROETHYL)PIPERAZINE