Despropylene Gatifloxacin Chemical Properties

Melting point:

198-200C

Boiling point:

556.7±50.0 °C(Predicted)

Density 

1.509±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)

form 

Solid

pka

6.40±0.50(Predicted)

color 

Pale Yellow to Brown

Despropylene Gatifloxacin Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

A metabolite of Gatifloxacin; a new quinolone with antibacterial activity.

Synthesis

To a solution of 7-chloro-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (1,7 g) in 1-methyl-2-pyrrolidinone (20 mL) was added ethylenediamine (2,1 g). The mixture was heated at 130C for 10 hours. The reaction mixture was cooled and then poured into DCM (20 mL). The resulting precipitate was dispersed in MeOH and filtered to give 7-chloro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (830 mg). To a solution of 7-chloro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (2,0 g) in 1-methyl-2-pyrrolidone (20 mL) was added ethylenediamine (2,3 g). The mixture was heated at 130C for 10 hours. The reaction mixture was cooled and poured into DCM (20 mL). The resulting precipitate was dispersed in MeOH and filtered to obtain 1,2-ethylenediamine gatifloxacin (910 mg).

Despropylene Gatifloxacin(172426-86-7)Related Product Information

• 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
• Ofloxacin
• 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid
• Gatifloxacin
• 1-Cyclopropyl-6-fluoro-8-Methoxy-4-oxo-7-(piperazin-1-yl)1,4-dihydroquinoline-3-carboxylic acid
• GATIFLOXACIN RELATED COMPOUND A
• 7-[(2-Aminopropyl)amino]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic Acid