Trimethoprim-d3 Chemical Properties

Melting point:

208-210°C

storage temp. 

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Pale Yellow

Trimethoprim-d3 Usage And Synthesis

Description

Trimethoprim-d₃ is intended for use as an internal standard for the quantification of trimethoprim by GC- or LC-MS. Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid. Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC₅₀s = 5 and 30,000 nM, respectively). Formulations containing trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, have been used in the treatment of urinary tract infections.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Trimethoprim-d3 (Major) is an antibacterial.

Uses

Deuterated Trimethoprim, an antibacterial

References

[1] THANH LAM. Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines[J]. Journal of Medicinal Chemistry, 2014, 57 3: 651-668. DOI: 10.1021/jm401204g
[2] BARRY I. SCHWEITZER  Joseph R B  Adam P Dicker. Dihydrofolate reductase as a therapeutic target[J]. FASEB Journal, 1990, 4 8: 2441-2452. DOI: 10.1096/fasebj.4.8.2185970

Trimethoprim-d3(1189923-38-3)Related Product Information

• Trimethoprim
• Trimethoprim tablets
• Sulfolex-13C6
• SulfaMethoxazole-13C6
• SULFAMETHAZINE (Phenyl-13C6, 99%)