5'-O-Dimethoxytrityl-N-isobutyryl-deoxyguanosine Chemical Properties

Melting point:

~150 °C (dec.)(lit.)

Boiling point:

671.92°C (rough estimate)

Density 

1.2353 (rough estimate)

refractive index 

1.7500 (estimate)

storage temp. 

Inert atmosphere,2-8°C

solubility 

soluble in Methanol

form 

powder to crystal

pka

9.16±0.20(Predicted)

color 

White

Water Solubility 

2.4mg/L at 20℃

InChIKey

RMQXDNUKLIDXOS-PTIWCXHYNA-N

SMILES

C(OC[C@@H]1[C@@H](O)C[C@H](N2C=NC3C(=O)NC(NC(=O)C(C)C)=NC2=3)O1)(C1=CC=CC=C1)(C1C=CC(OC)=CC=1)C1=CC=C(OC)C=C1 |&1:3,4,7,r|

LogP

2.98 at 20℃

CAS DataBase Reference

68892-41-1(CAS DataBase Reference)

EPA Substance Registry System

Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)- (68892-41-1)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

1-3-10

HS Code 

29349990

MSDS

• Language:English Provider:5'-O-Dimethoxytrityl-N-isobutyryl-deoxyguanosine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

5'-O-Dimethoxytrityl-N-isobutyryl-deoxyguanosine Usage And Synthesis

Uses

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine (5'-O-Dimethoxytrityl-N-isobutyryl-deoxyguanosine) can be used as fluorescent hydrogel with high intensity.

Flammability and Explosibility

Not classified

Synthesis

2N-Isobutyryl deoxyguanosine (B5-I) was dried by co-evaporation with dry pyridine three times. To a stirred suspension of dry (B5-I) (14.15 mmol) in pyridine (100 mL), a solution of dimetoxytrityl chloride (14.8 mmol) in pyridine (30 mL) was added dropwise over 60 min. The reaction mixture was left for 4 h at room temperature, cooled to 0 C. by immersion in an ice water bath, quenched with 5% NaHCO3 (100 mL), and extracted with ethyl acetate (3×100 mL). The organic fractions were pooled, dried over magnesium sulfate, and concentrated in a vacuum, and the residue was co-evaporated with toluene. The gum oil residue was dissolved in a minimum amount of methylenechloride and added dropwise to a mixture of ethyl and petroleum ether (2000 mL 75/25) with stirring. After 20 min, pure 5'-O-Dimethoxytrityl-N-isobutyryl-deoxyguanosine precipitated from the solution and was filtered off and dried. Yield: 75%

5'-O-Dimethoxytrityl-N-isobutyryl-deoxyguanosine(68892-41-1)Related Product Information

• 5'-O-Dimethoxytrityl-deoxythymidine
• 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine
• 2'-Deoxyguanosine
• N2-Isobutyryl-2'-deoxyguanosine
• Isobutyramide
• N2-ISOBUTYRYL-2'-DEOXYGUANOSINE
• DMT-dG(ib) Phosphoramidite
• 5'-O-Dimethoxytrityl-N-isobutyryl-deoxyguanosine
• 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
• 5'-O-(DIMETHOXYTRITYL)-8-HYDROXY-N2-ISOBUTRYL-2'-DEOXYGUANOSINE
• IBU-DMT-DEOXYGUANOSINE SUCCINIC ACID
• 5'-DMT-RIBO GUANOSINE (N-IBU)
• 2'-Deoxyguanosine monohydrate
• 5'-O-FDMT-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE CEP
• 3'-DMT-DG(IBU)-SUC-CPG
• 5'-DMT-DG(IBU)-SUC-CPG
• N2-(ISOBUTYRYL)-5'-O-(DIMETHOXYTRITYL)-2'-O-(T-BUTYLDIMETHYLSILYL)-GUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE
• 5'-DIMETHOXYTRITYL-N2-ISOBUTYRYL-2'-(2-METHOXYETHYL)GUANOSINE