STATIL Chemical Properties

Melting point:

184-186℃ (DEC.)

Density 

1.60

storage temp. 

Store at RT

solubility 

DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL

form 

A crystalline solid

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

STATIL Usage And Synthesis

Description

Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with K_i values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F_2α by human cultured preadipocytes.

Uses

Inhibitor (aldose reductase).

Uses

Statil is a knon aldose reductase inhibitor which blocks the conversion of glucose to sorbitol. In addition it suppresses cell cancer growth

Definition

ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines.

Biological Activity

Potent aldose reductase inhibitor.

STATIL(72702-95-5)Related Product Information

• STATIL
• BENZYL-(2-FLUORO-BENZYL)-AMINE
• 4-BROMO-2-FLUOROBENZYLAMINE
• 1,1-Dibenzylhydrazine
• (4-BROMOBENZYL)METHYLAMINE
• (2-FLUORO-BENZYL)-HYDRAZINE
• (3-METHYL-4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID
• (4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETIC ACID
• 3-(2-FORMYLPHENYL)PROPANOIC ACID
• CHEMBRDG-BB 5937785
• 4-BROMO-BENZYL-HYDRAZINE
• 4-Bromo-2-fluorotoluene
• 4-ETHYL-2H-PHTHALAZIN-1-ONE