Tetrahydroberberine Chemical Properties

Melting point:

166.5 °C

Boiling point:

476.1±45.0 °C(Predicted)

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO: >10 mg/mL, soluble

form 

solid

pka

6.53±0.20(Predicted)

color 

yellow

biological source

(Corydalis yanhusuo)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

3

Toxicity

LD50 in mice (mg/kg): 940 orally; 790 s.c.; 100 i.v. (Sadritdinov, Sultanov)

MSDS

• Language:English Provider:SigmaAldrich

Tetrahydroberberine Usage And Synthesis

Uses

Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling.

Uses

Tetrahydroberberine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Tetrahydroberberine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling.

Definition

ChEBI: A berberine alkaloid that is 5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline substituted by methoxy groups at positions 9 and 10.

Biological Activity

Dopamine receptor antagonist; nicotinic acetylcholine receptor (α4β2, α4β4, α7, α1β, 1γδ) modulator; induces clearance of low-density lipoprotein in mice.

Tetrahydroberberine (Canadine), an isoquinoline alkaloid isolated from corydalis tuber, is a potent dopamine D2 receptor antagonist (pKi = 6.08) and nicotinic acetylcholine receptor (α4β2, α4β4, α7, α1β, 1γδ) modulator. Tetrahydroberberine alleviates high-f at diet-induced hyperlipidemia and induces clearance of low-density lipoprotein and intermediate-density lipoprotein in mice.

Tetrahydroberberine(522-97-4)Related Product Information

• (-)-Huperzine A
• Leflunomide
• Formoterol fumarate dihydrate
• Artemisinin
• Andrographolide
• Berbamine hydrochloride
• BERBERINE CHLORIDE
• Rotundine
• epiberberine
• Coptisine chloride
• Berberine hydrochloride
• TETRAHYDROBERBERINE(CANADINE)(P),TETRAHYDROBERBERINE(CANADINE)(P)
• 7-(4-chlorobenzyl)-7,8,13,13a-tetrahydroberberine
• DL-TETRAHYDROBERBERINE,TETRAHYDROBERBERINE,CANADINE,DL-CANADINE
• .Alpha.-Canadine methochloride
• 1-tetrahydroberberine-camphor sulfonate
• canadine hydrochloride
• (D,L)-TETRAHYDROBERBERINE(CANADINE),(D,L)-TETRAHYDROBERBERINE(CANADINE)