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Tetrahydroberberine

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Tetrahydroberberine Basic information

Product Name:
Tetrahydroberberine
Synonyms:
  • (13aR)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine
  • l-Canadine
  • l-Tetrahydroberberine
  • l-Xanthopuccine
  • 6H-Benzo[G]-1,3-benzodioxolo[5,6-A]quinolizine, 5,8,13,13A-tetrahydro-9,10-dimethoxy-
  • Berberine, tetrahydro-
  • Berbine, 9,10-dimethoxy-2,3-(methylenedioxy)-
  • Nsc94918
CAS:
522-97-4
MF:
C20H21NO4
MW:
339.39
EINECS:
208-338-2
Product Categories:
  • Inhibitors
  • reference standards from Chinese medicinal herbs (TCM).
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • standardized herbal extract
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Neurochemicals
  • Pharmaceuticals
Mol File:
522-97-4.mol
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Tetrahydroberberine Chemical Properties

Melting point:
166.5 °C
Boiling point:
476.1±45.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >10 mg/mL, soluble
pka
6.53±0.20(Predicted)
form 
solid
color 
yellow
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
Toxicity
LD50 in mice (mg/kg): 940 orally; 790 s.c.; 100 i.v. (Sadritdinov, Sultanov)

MSDS

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Tetrahydroberberine Usage And Synthesis

Uses

Tetrahydroberberine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Tetrahydroberberine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling.

Definition

ChEBI: A berberine alkaloid that is 5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline substituted by methoxy groups at positions 9 and 10.

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