H-GLU-TRP-OH
H-GLU-TRP-OH Basic information
- Product Name:
- H-GLU-TRP-OH
- Synonyms:
-
- alpha-glutamyltryptophan
- GLU-TRP
- H-GLU-TRP-OH
- Ccris 8677
- Glutamyl tryptophan
- Glutamyltryptophan
- L-alpha-Glutamyl-L-tryptophan
- L-Tryptophan, N-L-alpha-glutamyl-
- CAS:
- 38101-59-6
- MF:
- C16H19N3O5
- MW:
- 333.34
- Mol File:
- 38101-59-6.mol
More
Less
H-GLU-TRP-OH Chemical Properties
- Melting point:
- 121-122℃
- Boiling point:
- 738.9±60.0 °C(Predicted)
- Density
- 1.428
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO : 15.5 mg/mL (46.50 mM)
- form
- Solid
- pka
- 3.09±0.10(Predicted)
- color
- White to off-white
- InChI
- InChI=1/C16H19N3O5/c17-11(5-6-14(20)21)15(22)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/s3
- InChIKey
- LLEUXCDZPQOJMY-PZILLZCRNA-N
- SMILES
- C(C1=CNC2=CC=CC=C12)[C@@H](C(=O)O)NC(=O)[C@@H](N)CCC(=O)O |&1:10,17,r|
More
Less
H-GLU-TRP-OH Usage And Synthesis
Uses
Treatment of Kaposi’s sarcoma and solid tumor cancers (angiogenesis inhibitor); immunomodulator.
Uses
H-Glu-Trp-OH, has show to have potential antiangiogenic and immunomodulating activities. It inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis. This agent has also been reported to stimulate the immune response to hepatitic C virus and intracellular bacterial infections.
Definition
ChEBI: A dipeptide composed of L-glutamic acid and L-tryptophan joined by a peptide linkage.
in vivo
Oglufanide (L-glu-L-trp) (1-100 mg/kg/day; s.c.; 10 days) has antitumor activity in immunocompetent and immunodeficient mice[4].
| Animal Model: | C57BL/6 immune competent mice, Lewis lung carcinoma (LLC) xenograft; Balb/C athymic mice, M21 human melanoma xenograft[4] |
| Dosage: | 1, 10, 50 and 100 mg/kg/day |
| Administration: | Subcutaneous injection, 10 days |
| Result: | Resulted in a dose-dependent inhibition of LLC tumor growth in syngeneic immune competent mice and showed a dose-dependent decrease in tumor volumes of xenografts in Balb/C athymic mice implanted with M21 human melanoma cells. |
IC 50
VEGFR; HCV; Human Endogenous Metabolite
H-GLU-TRP-OHSupplier
Hangzhou Peptidego Biotech Co.,Ltd. Gold
- Tel
- 0571-87213919
- Eric@peptidego.com
Wuhan Dingxintong Pharmaceutical Co. , Ltd. Gold
- Tel
- 15871722230
- 15871722230@163.com
Minglong (Xianning) Pharmaceutical Co., LTD Gold
- Tel
- 186-7296-9259 18771307593
- 3919539926@qq.com
GL Biochem (Shanghai) Ltd
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
More
Less
H-GLU-TRP-OH(38101-59-6)Related Product Information
- H-Glu-Oipr
- H-GLU-GLY-OH
- (4S)-4-amino-5-(benzyloxy)-5-oxopentanoic acid hydrochloride
- H-GLU-ALA-OH
- H-Glu-OMe
- H-Glu-OEt
- L-Glutamic acid alpha-amide
- L-Glutamic acid α-tert·butyl ester
- H-GAMMA-D-GLU-TRP-OH,H-GAMMA-GLU-TRP-OH,H-GLU(TRP-OH)-OH,H-D-GLU(TRP-OH)-OH
- H-GAMMA-GLU-TRP-OH,H-D-GLU(TRP-OH)-OH,H-GAMMA-D-GLU-TRP-OH,H-GLU(TRP-OH)-OH,H-g-D-Glu-Trp-OH
- H-GLU-TRP-OH
- H-VAL-PRO-TRP-PRO-ASN-ALA-SER-LEU-THR-PRO-LYS-TRP-ASN-ASN-GLU-THR-TRP-GLN-GLU-TRP-OH
- H-TYR-GLU-TRP-OH
- CBZ-L-GLU-TRP
- H-TYR-GLU-GLU-TRP-OH