1,2-Dimethylimidazole Chemical Properties

Melting point:

37-39 °C (lit.)

Boiling point:

204 °C (lit.)

Density 

1.084 g/mL at 25 °C (lit.)

vapor pressure 

1 mm Hg ( 20 °C)

refractive index 

1.5000 (estimate)

Flash point:

198 °F

storage temp. 

Store below +30°C.

pka

7.76±0.25(Predicted)

form 

Low Melting Mass

Specific Gravity

1.084

color 

Colorless to yellow

PH

12.6 (500g/l, H2O, 20℃)

Odor

Amine-like odor

Water Solubility 

Soluble in water.

BRN 

108457

InChIKey

GIWQSPITLQVMSG-UHFFFAOYSA-N

LogP

0.11 at 25℃

CAS DataBase Reference

1739-84-0(CAS DataBase Reference)

NIST Chemistry Reference

1H-Imidazole, 1,2-dimethyl-(1739-84-0)

EPA Substance Registry System

1H-Imidazole, 1,2-dimethyl- (1739-84-0)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-38-41

Safety Statements 

24-26-2

RIDADR 

UN 3263 8/PG 2

WGK Germany 

2

RTECS 

NI4838854

Autoignition Temperature

896 °F

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29332990

Toxicity

LD50 orally in Rabbit: 1300 mg/kg

MSDS

• Language:English Provider:1,2-Dimethylimidazole
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1,2-Dimethylimidazole Usage And Synthesis

Chemical Properties

colorless to yellow low melting mass

Uses

1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.

Uses

1,2-Dimethylimidazole was used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It was also used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.

Definition

ChEBI: 1,2-dimethylimidazole is a member of imidazoles.

General Description

1,2-Dimethylimidazole reacts with copper(II) tetraacetate to yield cis-bis(acetato)bis(1,2-dimethylimidazole) copper(II) complex. It undergoes Menschutkin reaction with benzyl bromide to yield 3-benzyl-1,2-dimethylimidazolium bromide and kinetics of reaction was studied in various ionic liquids and molecular organic solvents.

Flammability and Explosibility

Not classified

Synthesis

A high-pressure microreactor equipped with three micro-mixers was used for the synthesis. It was operated as follows: an aqueous methylamine solution (0.33 mol/L) was fed from tank 1 via pump 1 at a flow rate of 0.68 mL/min; an aqueous acetaldehyde solution (0.33 mol/L) was fed from tank 3 via pump 3A at a flow rate of 63 mL/min while nearby water (0.33 mol/L) flowed at a flow rate of 1.13 mL/min; an aqueous glyoxal solution ( 0.33 mol/L) was fed from tank 4 via pump 4 at a flow rate of 0.56 mL/min. The reaction pressure was set to 30 MPa and the final flow rate was 8.0 mL/min. The temperature of the first micro-mixer and the 2.4 m reaction tube was controlled at 25 °C by the thermostat chamber 1 , under which the mixing and reaction of methylamine with acetaldehyde was carried out. Subsequently, in the second micro-mixer, the reaction mixture was mixed with ammonia and kept at 25 °C in the constant temperature chamber 2, and the reaction was fully mixed and reacted in the 0.1 m reaction tube. Next, glyoxal was added to the reaction system and fully reacted in a 0 m reaction tube. Subsequently, the temperature of the reaction zone was raised to 70 °C and the reaction was continued in a 25 μm reaction tube. Finally, the reaction mixture was cooled to 5 °C by a heat exchanger, depressurized to atmospheric pressure by a pressure reducing valve, and the aqueous solution obtained under cooling in ice water (0 °C to 4 °C) was collected. The residence time of the reaction part was 37 seconds throughout the reaction. For analysis, the product was diluted 10-fold with ice water, if necessary, and analyzed immediately using a gas chromatograph. The reaction tube was made of stainless steel (SUS316) with an inner diameter of 0.5 mm. the yield of the product 1,2-dimethylimidazole was 85.1%. The quantitative analysis was performed on an Agilent gas chromatograph (GC 6890, hydrogen flame ionization detector) with an HP-INNOWAX column (inner diameter 0.32 mm, film thickness 0.25 μm, length 30 m) manufactured by J & W Co. The yield of each product (1,2-dimethylimidazole, 1-methylimidazole, 2-methylimidazole, and imidazole) was determined by preparing standard curves for each product. The yield of each product was calculated based on the concentration obtained by conversion of the standard curve as follows: 1,2-dimethylimidazole 85.1%, 1-methylimidazole 6.27%, 2-methylimidazole 6.59%, and imidazole 2.06%.

Purification Methods

Crystallise the imidazole from *benzene, dry and store it at 0-4o. The picrate crystallises from H2O or EtOH with m 181o. [Balaban & Pymann J Chem Soc 125 1570 1924, Gorun et al. J Am Chem Soc 109 4244 1987, Beilstein 23 H 66, 23 II 56, 23 III/IV 594.]

References

[1] Patent: JP2016/222615, 2016, A. Location in patent: Paragraph 0051-0052

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